| pubmed-article:2558044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C1955875 | lld:lifeskim |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C0140278 | lld:lifeskim |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C0599566 | lld:lifeskim |
| pubmed-article:2558044 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:2558044 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2558044 | pubmed:dateCreated | 1990-2-14 | lld:pubmed |
| pubmed-article:2558044 | pubmed:abstractText | Expression vectors have been constructed for a region of the human retinoic acid receptor-alpha (hRAR-alpha) and transferred into F9 embryonal carcinoma (EC) cells. When the vectors are overexpressed in F9 cells, clones can be selected for resistance to retinoic acid-induced differentiation. This effect is obtained even when the hRAR-alpha region is expressed as a beta-galactosidase fusion protein. Using the beta-galactosidase component of the fusion protein as a marker, overexpression of the fusion protein has been correlated with the retinoic acid-resistance effect. The clones resistant to retinoic acid no longer exhibit the normal retinoic acid induction of endo B cytokeratin, laminin B-1, and tissue plasminogen activator mRNAs observed with normal F9 cells. Retinoic acid induction of type IV alpha-1 collagen and Hox-1.3 RNAs is observed with these clones. When transfected with a thyroid receptor DNA-binding sequence (TRE)/thymidine kinase promoter/luciferase construct, the retinoic acid-resistant clones do not yield the same retinoic acid-induced level of luciferase obtained with F9 cells. It is hypothesized that the RAR vectors are interfering with endogenous RAR(s) in a dominant-negative manner to inhibit retinoic acid-induced differentiation of F9 EC cells. | lld:pubmed |
| pubmed-article:2558044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2558044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2558044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2558044 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2558044 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2558044 | pubmed:author | pubmed-author:LinneyEE | lld:pubmed |
| pubmed-article:2558044 | pubmed:author | pubmed-author:MurphyS PSP | lld:pubmed |
| pubmed-article:2558044 | pubmed:author | pubmed-author:EspesethA SAS | lld:pubmed |
| pubmed-article:2558044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2558044 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:2558044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2558044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2558044 | pubmed:pagination | 1647-56 | lld:pubmed |
| pubmed-article:2558044 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:meshHeading | pubmed-meshheading:2558044-... | lld:pubmed |
| pubmed-article:2558044 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2558044 | pubmed:articleTitle | Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. | lld:pubmed |
| pubmed-article:2558044 | pubmed:affiliation | Department of Microbiology and Immunology, Duke University Medical Center, North Carolina 27710. | lld:pubmed |
| pubmed-article:2558044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2558044 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2558044 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2558044 | lld:pubmed |
