| pubmed-article:2557727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C0027548 | lld:lifeskim |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C0227284 | lld:lifeskim |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:2557727 | lifeskim:mentions | umls-concept:C1979842 | lld:lifeskim |
| pubmed-article:2557727 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2557727 | pubmed:dateCreated | 1990-2-5 | lld:pubmed |
| pubmed-article:2557727 | pubmed:abstractText | Proximal duodenum from the amphibian Necturus was stripped of muscle layers and the mucosa was mounted as a tube for studies of alkali transport or as a flat sheet for intracellular impalement by voltage-sensitive glass micro-electrodes. The mucosa alkalinized the unbuffered luminal perfusate at a high rate (3.4 muequiv. cm-1 h-1) and developed a transepithelial electric potential difference of 5.7 mV (lumen negative). Transport was inhibited by 2,4-dinitrophenol (10(-4) M) and by furosemide (10(-3) M) and SITS (10(-3) M) on the seros but not on the mucosal side, indicating dependence on tissue metabolism and on serosal membrane Cl-/HCO3- exchange. Prostaglandin E2 (10(-7)-10(-5) M) and dibutyryl cyclic AMP (10(-6)-10(-4) M) had no effects on the secretion or transepithelial electrical potential difference. removal of serosal HCO3- decreased luminal alkalinization by 75%, indicating a contribution by passive migration of HCO3- and/or a dependence of transcellular transport on the nutrient supply of this ion. Administration of HCO3- (17.8 mM) to the luminal perfusate affected neither the transepithelial nor transmembrane electrical potential differences nor the resistance ratio. It is thus unlikely that the luminal membrane possesses any major HCO3- conductance. | lld:pubmed |
| pubmed-article:2557727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2557727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2557727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2557727 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2557727 | pubmed:issn | 0001-6772 | lld:pubmed |
| pubmed-article:2557727 | pubmed:author | pubmed-author:FlemströmGG | lld:pubmed |
| pubmed-article:2557727 | pubmed:author | pubmed-author:BridénSS | lld:pubmed |
| pubmed-article:2557727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2557727 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:2557727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2557727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2557727 | pubmed:pagination | 481-7 | lld:pubmed |
| pubmed-article:2557727 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:meshHeading | pubmed-meshheading:2557727-... | lld:pubmed |
| pubmed-article:2557727 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2557727 | pubmed:articleTitle | Alkaline secretion by Necturus proximal duodenal mucosa. | lld:pubmed |
| pubmed-article:2557727 | pubmed:affiliation | Department of Physiology and Medical Biophysics, Uppsala University Biomedical Centre, Sweden. | lld:pubmed |
| pubmed-article:2557727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2557727 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
