| pubmed-article:2556718 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2556718 | lifeskim:mentions | umls-concept:C1214589 | lld:lifeskim |
| pubmed-article:2556718 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:2556718 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:2556718 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:2556718 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2556718 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:2556718 | pubmed:dateCreated | 1990-1-19 | lld:pubmed |
| pubmed-article:2556718 | pubmed:abstractText | In a previous paper, a model was presented showing how the group of Ca2+/calmodulin-dependent protein kinase II molecules contained within a postsynaptic density could stably store a graded synaptic weight. This paper completes the model by showing how bidirectional control of synaptic weight could be achieved. It is proposed that the quantitative level of the activity-dependent rise in postsynaptic Ca2+ determines whether the synaptic weight will increase or decrease. It is further proposed that reduction of synaptic weight is governed by protein phosphatase 1, an enzyme indirectly controlled by Ca2+ through reactions involving phosphatase inhibitor 1, cAMP-dependent protein kinase, calcineurin, and adenylate cyclase. Modeling of this biochemical system shows that it can function as an analog computer that can store a synaptic weight and modify it in accord with the Hebb and anti-Hebb learning rules. | lld:pubmed |
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| pubmed-article:2556718 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2556718 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2556718 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2556718 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2556718 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2556718 | pubmed:author | pubmed-author:LismanJJ | lld:pubmed |
| pubmed-article:2556718 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2556718 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2556718 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2556718 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2556718 | pubmed:pagination | 9574-8 | lld:pubmed |
| pubmed-article:2556718 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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