| pubmed-article:2552327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2552327 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:2552327 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2552327 | lifeskim:mentions | umls-concept:C0678941 | lld:lifeskim |
| pubmed-article:2552327 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:2552327 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:2552327 | pubmed:issue | 6244 | lld:pubmed |
| pubmed-article:2552327 | pubmed:dateCreated | 1989-11-22 | lld:pubmed |
| pubmed-article:2552327 | pubmed:abstractText | Classical T lymphocytes recognize foreign antigens in the context of self major histocompatibility complex (MHC) molecules by means of the T-cell receptor (TCR)alpha beta heterodimer. The genes for TCR beta-chains, like immunoglobulin genes, are subject to allelic exclusion. The introduction of a functional TCR-beta gene into the germline of mice prevents rearrangement of endogenous TCR-beta genes. Here we report that the introduction of a non-functional TCR-beta genes. Here we report that the introduction of a non-functional TCR-beta gene with a deletion of the major part of the variable region (delta V-TCR-beta), also inhibits endogenous TCR-beta gene rearrangement. This inhibition is mediated via the encoded protein because impairment of endogenous TCR-beta gene rearrangement is not found if a frameshift mutation is introduced into the DJ region of the delta V-TCR-beta transgene. The delta V-TCR-beta transgene can lead to two phenotypes, in which lymphoid development is perturbed. Phenotype A is characterized by a severe impairment of both T and B cell development as reflected by the complete absence of certain lymphoid organs. In phenotype B, lymphoid organs are macroscopically normal, but T cell differentiation is impeded. Virtually all thymocytes lack membrane expression of TCR-alpha beta, but nevertheless carry the CD4 and CD8 antigens (CD4+CD8+ phenotype); they do not, however, mature further. The defect in mice of phenotype B but not of phenotype A can be corrected by the introduction of a functional TCR-beta gene. | lld:pubmed |
| pubmed-article:2552327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2552327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2552327 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2552327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2552327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2552327 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2552327 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2552327 | pubmed:author | pubmed-author:BorstJJ | lld:pubmed |
| pubmed-article:2552327 | pubmed:author | pubmed-author:BernsAA | lld:pubmed |
| pubmed-article:2552327 | pubmed:author | pubmed-author:OssendorpFF | lld:pubmed |
| pubmed-article:2552327 | pubmed:author | pubmed-author:KrimpenfortPP | lld:pubmed |
| pubmed-article:2552327 | pubmed:author | pubmed-author:MeliefCC | lld:pubmed |
| pubmed-article:2552327 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2552327 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:2552327 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:2552327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2552327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2552327 | pubmed:pagination | 742-6 | lld:pubmed |
| pubmed-article:2552327 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:meshHeading | pubmed-meshheading:2552327-... | lld:pubmed |
| pubmed-article:2552327 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2552327 | pubmed:articleTitle | T cell depletion in transgenic mice carrying a mutant gene for TCR-beta. | lld:pubmed |
| pubmed-article:2552327 | pubmed:affiliation | Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. | lld:pubmed |
| pubmed-article:2552327 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2552327 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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