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pubmed-article:2547646pubmed:abstractTextIn order to investigate the role of peripheral GABA-B receptors, the effects of the putative GABA-B agonist baclofen on immunoreactive gastrin release from an isolated vascularly perfused rat stomach preparation were examined. The vascular infusion of baclofen at graded concentrations induced a dose-dependent increase in gastrin release; this was unaffected by the GABA-B antagonist delta-aminovaleric acid, but was fully prevented by the selective GABA-A antagonist bicuculline as well as by atropine or tetrodotoxin. These results suggest that the stimulant effects of baclofen are mediated by nervous cholinergic structures associated with GABA-A receptors, and indicate that this GABA-B agonist must be regarded as a partial agonist of peripheral GABA-A receptors.lld:pubmed
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pubmed-article:2547646pubmed:articleTitleGABA-A-mediated gastrin release induced by baclofen in the isolated vascularly perfused rat stomach.lld:pubmed
pubmed-article:2547646pubmed:affiliationInstitute of Medical Pharmacology, Veterinary Medical School, Pisa, Italy.lld:pubmed
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