| pubmed-article:2545439 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C1882801 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C0169533 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2545439 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:2545439 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2545439 | pubmed:dateCreated | 1989-8-16 | lld:pubmed |
| pubmed-article:2545439 | pubmed:abstractText | The bipotential glial progenitor cells (O-2A progenitors), which during development of the rat optic nerve give rise to oligodendrocytes and type 2 astrocytes, are stimulated to divide in culture by platelet-derived growth factor (PDGF), and there is evidence that PDGF is important for development of the O-2A cell lineage in vivo. We have visualized PDGF mRNA in the rat optic nerve by in situ hybridization, and its spatial distribution is compatible with the idea that type 1 astrocytes are the major source of PDGF in the nerve. We can detect mRNA encoding the A chain, but not the B chain of PDGF in the brain and optic nerve, suggesting that the major form of PDGF in the central nervous system is a homodimer of A chains (PDGF-AA). PDGF-AA is a more potent mitogen for O-2A progenitor cells than is PDGF-BB, while the reverse is true for human or rat fibroblasts. Fibroblasts display two types of PDGF receptors, type A receptors which bind to all three dimeric isoforms of PDGF, and type B receptors which bind PDGF-BB and PDGF-AB, but have low affinity for PDGF-AA. Our results suggest that O-2A progenitor cells possess predominantly type A receptors, and proliferate during development in response to PDGF-AA secreted by type 1 astrocytes. | lld:pubmed |
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| pubmed-article:2545439 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2545439 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2545439 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2545439 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2545439 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2545439 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:WestermarkBB | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:HeldinC HCH | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:RichardsonW... | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:CollariniE... | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:PringleNN | lld:pubmed |
| pubmed-article:2545439 | pubmed:author | pubmed-author:MosleyM JMJ | lld:pubmed |
| pubmed-article:2545439 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2545439 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:2545439 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2545439 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2545439 | pubmed:pagination | 1049-56 | lld:pubmed |
| pubmed-article:2545439 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:2545439 | pubmed:meshHeading | pubmed-meshheading:2545439-... | lld:pubmed |
| pubmed-article:2545439 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2545439 | pubmed:articleTitle | PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve. | lld:pubmed |
| pubmed-article:2545439 | pubmed:affiliation | Department of Biology, University College London, UK. | lld:pubmed |
| pubmed-article:2545439 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2545439 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
