| pubmed-article:2543764 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0142661 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0075131 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:2543764 | lifeskim:mentions | umls-concept:C0111339 | lld:lifeskim |
| pubmed-article:2543764 | pubmed:dateCreated | 1989-7-21 | lld:pubmed |
| pubmed-article:2543764 | pubmed:abstractText | The La antigen is known to associate, at least transiently, with a series of small nuclear and cytoplasmic ribonucleoprotein particles (snRNPs and scRNPs), e.g. U1 and U6 snRNPs. In CV-1 cells a monoclonal antibody (MAb), directed against the La protein (La1B5), immunostained intranuclear speckles. These speckles were found to co-localize with speckles that were stained by MAbs directed against either all U snRNPs or only against U1 snRNPs. Two h after infection of CV-1 cells with herpes simplex virus type 1 (HSV-1) (strain HFEM) the staining of nuclear speckles with the anti-La MAb disappeared and the La protein was found quantitatively in the cytoplasm. In contrast nuclear speckles remained stained with the MAbs against the U snRNPs. Similar results were obtained using HSV-1 strains Lenette or 17 syn+ or temperature-sensitive (ts) mutants defective either in DNA synthesis (tsS) or in the immediate early protein (Mr 175 K) (tsK). Later in infection the La protein returned to the nucleus. Six h after infection most of the nuclear La protein was found to localize within patchy regions. These areas seem to be related to heterogeneous nuclear RNA transcription and/or processing sites, but not to DNA replication sites. | lld:pubmed |
| pubmed-article:2543764 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2543764 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2543764 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2543764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2543764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2543764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2543764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2543764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2543764 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2543764 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2543764 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:2543764 | pubmed:author | pubmed-author:MüllerW EWE | lld:pubmed |
| pubmed-article:2543764 | pubmed:author | pubmed-author:FalkeDD | lld:pubmed |
| pubmed-article:2543764 | pubmed:author | pubmed-author:BachmannMM | lld:pubmed |
| pubmed-article:2543764 | pubmed:author | pubmed-author:SchröderH CHC | lld:pubmed |
| pubmed-article:2543764 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2543764 | pubmed:volume | 70 ( Pt 4) | lld:pubmed |
| pubmed-article:2543764 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2543764 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2543764 | pubmed:pagination | 881-91 | lld:pubmed |
| pubmed-article:2543764 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2543764 | pubmed:meshHeading | pubmed-meshheading:2543764-... | lld:pubmed |
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| pubmed-article:2543764 | pubmed:meshHeading | pubmed-meshheading:2543764-... | lld:pubmed |
| pubmed-article:2543764 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2543764 | pubmed:articleTitle | Intracellular distribution of the La antigen in CV-1 cells after herpes simplex virus type 1 infection compared with the localization of U small nuclear ribonucleoprotein particles. | lld:pubmed |
| pubmed-article:2543764 | pubmed:affiliation | Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität, Mainz, F.R.G. | lld:pubmed |
| pubmed-article:2543764 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2543764 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2543764 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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