| pubmed-article:2542691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C0046196 | lld:lifeskim |
| pubmed-article:2542691 | lifeskim:mentions | umls-concept:C0097109 | lld:lifeskim |
| pubmed-article:2542691 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2542691 | pubmed:dateCreated | 1989-7-12 | lld:pubmed |
| pubmed-article:2542691 | pubmed:abstractText | The binding of catechol estrogens, epoxyenones and methoxyestrogens was evaluated using estrogen receptors in cytosol prepared from human breast cancers. The relative affinity of 2-hydroxyestradiol, a metabolite formed in vitro from estradiol-17 beta by breast cancer cells, was indistinguishable from that of estradiol-17 beta. 4-Hydroxyestradiol, which is also a metabolite of estradiol-17 beta, associated with the estrogen receptor with a relative affinity approximately 1.5-fold greater than that of estradiol-17 beta. Epoxyenones and methoxyestrogens were weak competitors compared to the binding of estradiol-17 beta, exhibiting relative affinities 3% or less than the affinity of estradiol-17 beta. Sucrose density gradient centrifugation revealed that both 2- and 4-hydroxyestradiol inhibited the binding of estradiol-17 beta to both the 4S and 8S isoforms of the estrogen receptor in a competitive manner, with a Ki = 0.94 nM for 2-hydroxyestradiol and a Ki = 0.48 nM for 4-hydroxyestradiol. It can be concluded that these data demonstrate a specific receptor-mediated estrogenic action for both of these catechol estrogens. | lld:pubmed |
| pubmed-article:2542691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2542691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2542691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2542691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2542691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2542691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2542691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2542691 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2542691 | pubmed:issn | 0022-4731 | lld:pubmed |
| pubmed-article:2542691 | pubmed:author | pubmed-author:WittliffJ LJL | lld:pubmed |
| pubmed-article:2542691 | pubmed:author | pubmed-author:PurdyR HRH | lld:pubmed |
| pubmed-article:2542691 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:2542691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2542691 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:2542691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2542691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2542691 | pubmed:pagination | 485-92 | lld:pubmed |
| pubmed-article:2542691 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2542691 | pubmed:meshHeading | pubmed-meshheading:2542691-... | lld:pubmed |
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| pubmed-article:2542691 | pubmed:meshHeading | pubmed-meshheading:2542691-... | lld:pubmed |
| pubmed-article:2542691 | pubmed:meshHeading | pubmed-meshheading:2542691-... | lld:pubmed |
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| pubmed-article:2542691 | pubmed:meshHeading | pubmed-meshheading:2542691-... | lld:pubmed |
| pubmed-article:2542691 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2542691 | pubmed:articleTitle | Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. | lld:pubmed |
| pubmed-article:2542691 | pubmed:affiliation | Department of Biochemistry, University of Louisville, KY 40292. | lld:pubmed |
| pubmed-article:2542691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2542691 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2542691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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