| pubmed-article:2541807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2541807 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2541807 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:2541807 | lifeskim:mentions | umls-concept:C0041696 | lld:lifeskim |
| pubmed-article:2541807 | lifeskim:mentions | umls-concept:C0178587 | lld:lifeskim |
| pubmed-article:2541807 | lifeskim:mentions | umls-concept:C2705716 | lld:lifeskim |
| pubmed-article:2541807 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2541807 | pubmed:dateCreated | 1989-7-6 | lld:pubmed |
| pubmed-article:2541807 | pubmed:abstractText | Values of binding maximum (Bmax) and dissociation constant (Kd) of (-)3-[125I]iodocyanopindolol (ICYP) were determined in beta-adrenergic receptors of membranes of peripheral lymphocytes in 32 patients with unipolar depression (DSM-III-R) and 31 normal controls. Results were analyzed by a two-way Analysis of Covariance method. A significant difference was noted for group assignment (patient versus control, p less than 0.05). Mean Bmax (fmol ICYP bound/mg lymphocyte membrane fraction total protein) of patients was 31.9 +/- 3.84 (SE) and controls 46.3 +/- 3.92 (SE). A significant interaction was found between group membership and gender (p less than 0.05). In the female patient group (n = 14), mean Bmax was 30.5 +/- 5.79 (SE); in female controls, mean Bmax was 56.0 +/- 5.15 (SE). Differences between male patients and male controls were not significant. Mean values of Kd (pmol/liter) showed a trend for patient values to be lower than control values [69.0 +/- 13.66 (SE) versus 108.5 +/- 14.42 (SE), respectively]. A significant inverse relationship was noted between lymphocyte beta-receptor Bmax and frequency of panic attacks during the depressive episode in 18 patients (p = 0.05). No relationship was found between values of Kd and frequency of panic attacks in these patients. Thus, preliminary evidence is provided for relationships among altered beta-adrenergic receptor binding, gender, and indices of panic-anxiety in unipolar depressed patients. | lld:pubmed |
| pubmed-article:2541807 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2541807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541807 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2541807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2541807 | pubmed:month | May | lld:pubmed |
| pubmed-article:2541807 | pubmed:issn | 0006-3223 | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:HaackDD | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:WeilerP GPG | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:GoodmanTT | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:MaddockR JRJ | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:MagliozziJ... | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:DoranA RAR | lld:pubmed |
| pubmed-article:2541807 | pubmed:author | pubmed-author:GietzenDD | lld:pubmed |
| pubmed-article:2541807 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2541807 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:2541807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2541807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2541807 | pubmed:pagination | 15-25 | lld:pubmed |
| pubmed-article:2541807 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
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| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:meshHeading | pubmed-meshheading:2541807-... | lld:pubmed |
| pubmed-article:2541807 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2541807 | pubmed:articleTitle | Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. | lld:pubmed |
| pubmed-article:2541807 | pubmed:affiliation | Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817. | lld:pubmed |
| pubmed-article:2541807 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2541807 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2541807 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2541807 | lld:pubmed |
