| pubmed-article:2541345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2541345 | lifeskim:mentions | umls-concept:C0072453 | lld:lifeskim |
| pubmed-article:2541345 | lifeskim:mentions | umls-concept:C0919487 | lld:lifeskim |
| pubmed-article:2541345 | pubmed:issue | 6220 | lld:pubmed |
| pubmed-article:2541345 | pubmed:dateCreated | 1989-6-9 | lld:pubmed |
| pubmed-article:2541345 | pubmed:abstractText | Growth factor receptors with protein tyrosine kinase activity are central to the control of proliferation of both normal and malignant cells. Using anti-phosphotyrosine antibodies, we have previously identified a transmembrane glycoprotein with abnormally high protein tyrosine kinase activity in a human gastric tumour cell line (GTL-16). Electrophoresis under non-reducing conditions revealed that this kinase (relative molecular mass 145,000 (145 K)) is disulphide-linked to a 50K chain in an alpha beta-complex of 190K (p190). From its novel two-chain structure, we deduced that p190 was the prototype of a new class of tyrosine kinase receptors. We now show that p190 is indistinguishable from the protein encoded by the c-met proto-oncogene and that the alpha beta-subunit structure is conserved in other human cell lines. We also show that the high level of p190 found in the GTL-16 cell line is accompanied by amplification and overexpression of c-met. This provides the first example of a functional alteration of c-met in a human tumour cell line. | lld:pubmed |
| pubmed-article:2541345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2541345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541345 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2541345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2541345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2541345 | pubmed:month | May | lld:pubmed |
| pubmed-article:2541345 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2541345 | pubmed:author | pubmed-author:ComoglioP MPM | lld:pubmed |
| pubmed-article:2541345 | pubmed:author | pubmed-author:PonzettoCC | lld:pubmed |
| pubmed-article:2541345 | pubmed:author | pubmed-author:CooperC SCS | lld:pubmed |
| pubmed-article:2541345 | pubmed:author | pubmed-author:Di RenzoM FMF | lld:pubmed |
| pubmed-article:2541345 | pubmed:author | pubmed-author:GiordanoSS | lld:pubmed |
| pubmed-article:2541345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2541345 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:2541345 | pubmed:volume | 339 | lld:pubmed |
| pubmed-article:2541345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2541345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2541345 | pubmed:pagination | 155-6 | lld:pubmed |
| pubmed-article:2541345 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:meshHeading | pubmed-meshheading:2541345-... | lld:pubmed |
| pubmed-article:2541345 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2541345 | pubmed:articleTitle | Tyrosine kinase receptor indistinguishable from the c-met protein. | lld:pubmed |
| pubmed-article:2541345 | pubmed:affiliation | Department of Biomedical Sciences and Oncology, University of Torino, Italy. | lld:pubmed |
| pubmed-article:2541345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2541345 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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