| pubmed-article:2541141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C2752508 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0218633 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C1167322 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C1293122 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0596483 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2541141 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:2541141 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2541141 | pubmed:dateCreated | 1989-6-9 | lld:pubmed |
| pubmed-article:2541141 | pubmed:abstractText | When human granulocytes that have been primed with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSFrh) are activated by ligands that stimulate the respiratory burst, the amount of superoxide anion (O2-) they generate is significantly increased. We have found that the accelerated rate of O2- release occurring under these conditions is accompanied by an antecedent increase in membrane depolarization. We examined the nature of the enhancement of membrane depolarization in GM-CSFrh-primed granulocytes and investigated its relationship to the increase in O2- generation by N-formyl methionylleucylphenylalanine (fMLP)-activated granulocytes. We found that augmented depolarization could not be accounted for by a change in the resting membrane potential induced by the growth factor and was still present after either blocking passive transmembrane Na+ movement with dimethylamiloride or by increasing the membrane's permeability to K+ with valinomycin. When their ability to depolarize was virtually eliminated by dissipating the transmembrane K+ gradient, GM-CSFrh-pretreated cells continued to generate more O2- after fMLP than did control cells. These results indicate that augmentation of the granulocyte's ability to generate O2- anions, which is induced by priming with GM-CSFrh, is independent both of the resting transmembrane potential and of alterations in the extent of membrane potential change induced by stimuli such as fMLP. | lld:pubmed |
| pubmed-article:2541141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2541141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2541141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2541141 | pubmed:month | May | lld:pubmed |
| pubmed-article:2541141 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:SimonsE RER | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:SullivanRR | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:GriffinJ DJD | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:LeavittJ LJL | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:FredetteJ PJP | lld:pubmed |
| pubmed-article:2541141 | pubmed:author | pubmed-author:GadenneA SAS | lld:pubmed |
| pubmed-article:2541141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2541141 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:2541141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2541141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2541141 | pubmed:pagination | 361-9 | lld:pubmed |
| pubmed-article:2541141 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:meshHeading | pubmed-meshheading:2541141-... | lld:pubmed |
| pubmed-article:2541141 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2541141 | pubmed:articleTitle | Effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSFrh) on transmembrane electrical potentials in granulocytes: relationship between enhancement of ligand-mediated depolarization and augmentation of superoxide anion (O2-) production. | lld:pubmed |
| pubmed-article:2541141 | pubmed:affiliation | Department of Medicine, Boston University Medical School, Massachusetts. | lld:pubmed |
| pubmed-article:2541141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2541141 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2541141 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2541141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2541141 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2541141 | lld:pubmed |
