| pubmed-article:2541070 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0014898 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C0064819 | lld:lifeskim |
| pubmed-article:2541070 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:2541070 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2541070 | pubmed:dateCreated | 1989-6-19 | lld:pubmed |
| pubmed-article:2541070 | pubmed:abstractText | The selective cytotoxicity of the lysosomotropic methyl esters of leucine or its lysosomal condensation product leucyl-leucine has been used to investigate the effect of cytolytic cells on the clonal outgrowth, cellular proliferation and antibody secretion of Epstein-Barr virus (EBV)-transformed human B cells. Large granular lymphocytes (LGL), monocytes, and a subset of T cells (CD8/CD11+) were permanently eliminated by the ester treatment. These lysosome-rich cells severely inhibit the clonal outgrowth of EBV-infected B cells, as determined by Poisson distribution calculations. Furthermore, leucyl-leucine methyl ester-treated and EBV-infected lymphocytes showed a significant increase in proliferative capability as well as immunoglobulin (Ig) production (three to 11 times) compared to non-treated but similarly infected lymphocytes. Since the effect of leucyl-leucine methyl ester treatment was also detectable in low-density (100 B cells/well) cultures, the suppression was unlikely to be exerted by EBV-specific T-cell clones, but pointed rather to the natural killer (NK) cells as effectors. | lld:pubmed |
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| pubmed-article:2541070 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2541070 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2541070 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2541070 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2541070 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2541070 | pubmed:author | pubmed-author:CarlssonRR | lld:pubmed |
| pubmed-article:2541070 | pubmed:author | pubmed-author:KälinMM | lld:pubmed |
| pubmed-article:2541070 | pubmed:author | pubmed-author:DanielssonLL | lld:pubmed |
| pubmed-article:2541070 | pubmed:author | pubmed-author:BorrebaeckC... | lld:pubmed |
| pubmed-article:2541070 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2541070 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:2541070 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2541070 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2541070 | pubmed:pagination | 485-90 | lld:pubmed |
| pubmed-article:2541070 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2541070 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2541070 | pubmed:articleTitle | The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. | lld:pubmed |
| pubmed-article:2541070 | pubmed:affiliation | Department of Biotechnology, Lund University, Sweden. | lld:pubmed |
| pubmed-article:2541070 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2541070 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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