| pubmed-article:2538724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0028589 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C1537647 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0079160 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0179400 | lld:lifeskim |
| pubmed-article:2538724 | lifeskim:mentions | umls-concept:C0019763 | lld:lifeskim |
| pubmed-article:2538724 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2538724 | pubmed:dateCreated | 1989-5-1 | lld:pubmed |
| pubmed-article:2538724 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2538724 | pubmed:abstractText | The promoter regions of class II major histocompatibility complex genes contain two highly conserved sequences, the X and Y boxes, which may be involved in the control of class II gene expression. In this study, we correlate in vivo functional assays for cis-acting regulatory elements in the HLA-DR alpha gene with in vitro binding assays for trans-acting regulatory proteins. Mutagenesis and transient transfection analyses indicated that both the X and Y boxes were important for HLA-DR alpha promoter function in a B lymphoblastoid cell line. Although specific nuclear protein interactions with the X consensus sequence were not apparent, the Y box, which contained an inverted CCAAT sequence, did bind specifically to at least one nuclear protein. This Y box-binding protein was present in nuclear extracts of all cell types examined, including human B and T cells and HeLa cells. The molecular mass of the protein, as determined by photoactivated protein-DNA cross-linking, was approximately 40 to 50 kilodaltons. Mutagenesis of the Y box that decreased protein binding also decreased promoter activity, implying that protein binding to this DNA sequence is important for DR alpha promoter function. | lld:pubmed |
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| pubmed-article:2538724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2538724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2538724 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2538724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2538724 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2538724 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2538724 | pubmed:author | pubmed-author:BrownA MAM | lld:pubmed |
| pubmed-article:2538724 | pubmed:author | pubmed-author:MooreT LTL | lld:pubmed |
| pubmed-article:2538724 | pubmed:author | pubmed-author:TroyR JRJ | lld:pubmed |
| pubmed-article:2538724 | pubmed:author | pubmed-author:ShermanP APA | lld:pubmed |
| pubmed-article:2538724 | pubmed:author | pubmed-author:BastaP VPV | lld:pubmed |
| pubmed-article:2538724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2538724 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2538724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2538724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2538724 | pubmed:pagination | 50-6 | lld:pubmed |
| pubmed-article:2538724 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2538724 | pubmed:meshHeading | pubmed-meshheading:2538724-... | lld:pubmed |
| pubmed-article:2538724 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2538724 | pubmed:articleTitle | Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteins. | lld:pubmed |
| pubmed-article:2538724 | pubmed:affiliation | Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27599. | lld:pubmed |
| pubmed-article:2538724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2538724 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2538724 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2538724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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