| pubmed-article:2536298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C1420232 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2536298 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2536298 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2536298 | pubmed:dateCreated | 1989-3-8 | lld:pubmed |
| pubmed-article:2536298 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536298 | pubmed:abstractText | We present the complete sequence of a cDNA encoding the human amiloride-sensitive Na+/H+ antiporter. After functional complementation of a mouse fibroblast mutant by gene transfer, we isolated a 0.8 kb genomic probe from a third-cycle mouse transformant. The probe detects gene amplification in Na+/H+ antiporter "overexpressers" and a single class of mRNA of ca. 5.6 kb in human, mouse, and hamster cells. With this probe we isolated a 4 kb cDNA from a library constructed from a mouse transformant in which the transfected human gene was amplified. This cDNA includes a noncoding leader of 407 bp, a 2682 bp open reading frame, and a 3' noncoding sequence containing a mouse B1 repeated element. The amino acid sequence predicts a protein of Mr = 99,354 with an N-terminal amphipathic domain that contains 10 putative transmembrane-spanning segments and two potential glycosylation sites, followed by a hydrophilic stretch of 395 residues, presumably cytoplasmic. Stable expression of the transfected cDNA in Na+/H+ antiporter-deficient cells restored the key functional features of this transporter: H+i-activated Na+ influx, amiloride sensitivity, and pHi regulation. | lld:pubmed |
| pubmed-article:2536298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2536298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536298 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2536298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2536298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2536298 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2536298 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2536298 | pubmed:author | pubmed-author:SardetCC | lld:pubmed |
| pubmed-article:2536298 | pubmed:author | pubmed-author:PouysségurJJ | lld:pubmed |
| pubmed-article:2536298 | pubmed:author | pubmed-author:FrancheMM | lld:pubmed |
| pubmed-article:2536298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2536298 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:2536298 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:2536298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2536298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2536298 | pubmed:pagination | 271-80 | lld:pubmed |
| pubmed-article:2536298 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2536298 | pubmed:meshHeading | pubmed-meshheading:2536298-... | lld:pubmed |
| pubmed-article:2536298 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2536298 | pubmed:articleTitle | Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. | lld:pubmed |
| pubmed-article:2536298 | pubmed:affiliation | Centre de Biochimie-CNRS, Université de Nice, France. | lld:pubmed |
| pubmed-article:2536298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2536298 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6548 | entrezgene:pubmed | pubmed-article:2536298 | lld:entrezgene |
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