| pubmed-article:2536190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C0132173 | lld:lifeskim |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2536190 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2536190 | pubmed:issue | 4889 | lld:pubmed |
| pubmed-article:2536190 | pubmed:dateCreated | 1989-2-21 | lld:pubmed |
| pubmed-article:2536190 | pubmed:abstractText | Nerve growth factor (NGF) interacts with both high affinity (Kd = 10(-10)-10(-11)M) and low affinity (Kd = 10(-8)-10(-9)M) receptors; the binding of NGF to the high affinity receptor is correlated with biological actions of NGF. To determine whether a single NGF binding protein is common to both forms of the receptor, a full-length receptor cDNA was introduced in the NR18 cell line, an NGF receptor-deficient variant of the PC12 pheochromocytoma cell line. The transformant displayed (i) both high and low affinity receptors detectable by receptor binding; (ii) an affinity cross-linking pattern with 125I-labeled NGF similar to that of the parent PC12 cell line; and (iii) biological responsiveness to NGF as assayed by induction of c-fos transcription. These findings support the hypothesis that a single binding protein is common to both forms of the NGF receptor and suggest that an additional protein is required to produce the high affinity form of the NGF receptor. | lld:pubmed |
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| pubmed-article:2536190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2536190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2536190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2536190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2536190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2536190 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2536190 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2536190 | pubmed:author | pubmed-author:SchleiferL... | lld:pubmed |
| pubmed-article:2536190 | pubmed:author | pubmed-author:ChaoM VMV | lld:pubmed |
| pubmed-article:2536190 | pubmed:author | pubmed-author:HempsteadB... | lld:pubmed |
| pubmed-article:2536190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2536190 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:2536190 | pubmed:volume | 243 | lld:pubmed |
| pubmed-article:2536190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2536190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2536190 | pubmed:pagination | 373-5 | lld:pubmed |
| pubmed-article:2536190 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2536190 | pubmed:meshHeading | pubmed-meshheading:2536190-... | lld:pubmed |
| pubmed-article:2536190 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2536190 | pubmed:articleTitle | Expression of functional nerve growth factor receptors after gene transfer. | lld:pubmed |
| pubmed-article:2536190 | pubmed:affiliation | Division of Hematology/Oncology, Cornell University Medical College, New York, NY 10021. | lld:pubmed |
| pubmed-article:2536190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2536190 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2536190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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