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pubmed-article:2529798pubmed:abstractTextTwo hundred sixty-four patients with moderate to severe seasonal allergic rhinitis were treated with loratadine 5 mg plus pseudoephedrine 120 mg twice a day or placebo in a 28-day multicenter study. Four nasal and four non-nasal symptoms were evaluated for efficacy. At the last evaluable visit, the active treatment group had significantly lower (P = .05) mean combined nasal and non-nasal symptom scores than the placebo group. Also, the physician's rating of overall therapeutic response was significantly better in the active-treatment group (P = .03). Dry mouth, insomnia, and nervousness were reported by a significantly greater proportion (P less than or equal to .04) in the active-treatment group. Sedation occurred in 7% of patients in each treatment group and 6% of patients in each group discontinued the study because of adverse experiences. Loratadine plus pseudoephedrine was safe and significantly more effective than placebo in relieving the symptoms of allergic rhinitis.lld:pubmed
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pubmed-article:2529798pubmed:articleTitleLoratadine-pseudoephedrine combination versus placebo in patients with seasonal allergic rhinitis.lld:pubmed
pubmed-article:2529798pubmed:affiliationAllergy Division, Albany Medical College, New York.lld:pubmed
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