| pubmed-article:2527253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0013604 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2527253 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:2527253 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2527253 | pubmed:dateCreated | 1989-9-21 | lld:pubmed |
| pubmed-article:2527253 | pubmed:abstractText | The role of platelet glucose-6-phosphate dehydrogenase (G-6-PD) in mediating the effects of human platelets on oxidant-induced edema in the isolated perfused rabbit lung was investigated using dehydroepiandrosterone, a specific steroidal inhibitor of G-6-PD. Xanthine oxidase (0.003 and 0.012 U/ml) caused lung edema that was attenuated by coinfusion of washed human platelets. Platelets that were incubated with DEA to inhibit G-6-PD activity augmented xanthine oxidase-induced lung edema and pulmonary hypertension at both doses of xanthine oxidase. Infusion of papaverine to maintain stable pulmonary artery (PA) pressures, incubation of G-6-PD-inhibited platelets with acetylsalicylate, or infusion of a thromboxane-prostaglandin endoperoxide receptor site antagonist, SQ 29548, into the lung perfusate prevented augmentation of lung edema and the PA pressor response by G-6-PD-inhibited platelets. It was concluded that antioxidant-intact platelets attenuate oxidant-induced lung edema by preventing increased membrane permeability, and that G-6-PD-inhibited platelets augment lung edema through hydrostatic mechanisms mediated by release of platelet cyclooxygenase products. | lld:pubmed |
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| pubmed-article:2527253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2527253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2527253 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2527253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2527253 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2527253 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2527253 | pubmed:author | pubmed-author:HalushkaP VPV | lld:pubmed |
| pubmed-article:2527253 | pubmed:author | pubmed-author:CookJ AJA | lld:pubmed |
| pubmed-article:2527253 | pubmed:author | pubmed-author:HeffnerJ EJE | lld:pubmed |
| pubmed-article:2527253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2527253 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2527253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2527253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2527253 | pubmed:pagination | 757-64 | lld:pubmed |
| pubmed-article:2527253 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2527253 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2527253 | pubmed:articleTitle | Human platelets modulate edema formation in isolated rabbit lungs. | lld:pubmed |
| pubmed-article:2527253 | pubmed:affiliation | Department of Medicine, Medical University of South Carolina, Charleston 29425. | lld:pubmed |
| pubmed-article:2527253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2527253 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2527253 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
