| pubmed-article:2526769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C0028027 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C1609982 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2526769 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:2526769 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2526769 | pubmed:dateCreated | 1989-8-29 | lld:pubmed |
| pubmed-article:2526769 | pubmed:abstractText | In vivo and in vitro experiments have shown that nicotinamide enhances the regeneration of rat B cells. Nicotinamide has been administered to human subjects at a dose of 3 g/day for more than one year without any serious side effects. A trial was conducted to study if nicotinamide could protect B cells in Type I (insulin-dependent) diabetic patients with established diabetes, but still with residual insulin secretion, the latter being evaluated throughout the study period. A randomized double-blind study was carried out on 26 Type I diabetic patients aged 15 to 40 years who had been treated with insulin for 1 to 5 years but who had a residual insulin secretion characterized by a glucagon stimulated C-peptide level higher than 0.1 nmol/l. They were given either 3 g/day of nicotinamide or a placebo for nine months. At baseline the treated and control groups did not differ according to age, diabetes duration, insulin dose, HbA1c or C-peptide levels. Three patients dropped out of the study. At 9 months there were no significant changes in the insulin doses required. However, HbA1c rose in the control group (8.1 +/- 0.4 vs 9.8 +/- 0.5%, p less than 0.05) but not in the nicotinamide treated group (7.5 +/- 0.5 vs 6.9 +/- 0.4%).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2526769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2526769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2526769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2526769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2526769 | pubmed:month | May | lld:pubmed |
| pubmed-article:2526769 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:2526769 | pubmed:author | pubmed-author:VialettesBB | lld:pubmed |
| pubmed-article:2526769 | pubmed:author | pubmed-author:VaguePP | lld:pubmed |
| pubmed-article:2526769 | pubmed:author | pubmed-author:BernayPP | lld:pubmed |
| pubmed-article:2526769 | pubmed:author | pubmed-author:Lassmann-Vagu... | lld:pubmed |
| pubmed-article:2526769 | pubmed:author | pubmed-author:PickTT | lld:pubmed |
| pubmed-article:2526769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2526769 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:2526769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2526769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2526769 | pubmed:pagination | 316-21 | lld:pubmed |
| pubmed-article:2526769 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2526769 | pubmed:meshHeading | pubmed-meshheading:2526769-... | lld:pubmed |
| pubmed-article:2526769 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2526769 | pubmed:articleTitle | Effect of nicotinamide treatment on the residual insulin secretion in type 1 (insulin-dependent) diabetic patients. | lld:pubmed |
| pubmed-article:2526769 | pubmed:affiliation | Service de Diabétologie, Centre Hospital Universitaire Timone, Marseille, France. | lld:pubmed |
| pubmed-article:2526769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2526769 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2526769 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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