pubmed-article:2525310 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0058698 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0027930 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C0040383 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
pubmed-article:2525310 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
pubmed-article:2525310 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:2525310 | pubmed:dateCreated | 1989-7-20 | lld:pubmed |
pubmed-article:2525310 | pubmed:abstractText | The effects of neurotensin in vitro (1-100 nM) on the binding characteristics of [3H]N-propylnorapomorphine ([3H]NPA) were analysed in striatal membrane preparations of the adult male rat. Subsequently, it was investigated whether the modulatory effects of 10 nM neurotensin on [3H]NPA binding were altered by treatment with toluene in vivo (80 p.p.m., 3 days, 6 h day-1) and in vitro (19 mumol ml-1). Displacement of [3H]NPA binding by raclopride (IC50 about 15 nM) and SCH 23390 (without effect) indicated that [3H]NPA labelled only D2 dopamine receptors in the present study. Neurotensin was found to reduce the affinity of D2 receptors with a maximum response at 10 nM. At this concentration the KD value was increased by 30-40% without any consistent changes in the number of binding sites. The modulatory effect of neurotensin remained intact also following toluene treatment in vivo and in vitro, although at a higher KD range, since toluene alone increased the KD value of [3H]NPA binding by 40-50%. Thus, the mechanisms mediating the effects of neurotensin and toluene on the D2 receptor are likely to be different. When neurotensin and toluene treatments were combined, the KD values of [3H]NPA binding were about twice as high as in non-treated controls. These additive effects may lead to a severely decreased efficiency of dopamine D2-mediated neurotransmission in vivo. | lld:pubmed |
pubmed-article:2525310 | pubmed:language | eng | lld:pubmed |
pubmed-article:2525310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2525310 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2525310 | pubmed:month | Apr | lld:pubmed |
pubmed-article:2525310 | pubmed:issn | 0001-6772 | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:FuxeKK | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:GustafssonJ... | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:AgnatiL FLF | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:HanssonTT | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:BenfenatiFF | lld:pubmed |
pubmed-article:2525310 | pubmed:author | pubmed-author:von EulerGG | lld:pubmed |
pubmed-article:2525310 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2525310 | pubmed:volume | 135 | lld:pubmed |
pubmed-article:2525310 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2525310 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2525310 | pubmed:pagination | 443-8 | lld:pubmed |
pubmed-article:2525310 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
pubmed-article:2525310 | pubmed:meshHeading | pubmed-meshheading:2525310-... | lld:pubmed |
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pubmed-article:2525310 | pubmed:meshHeading | pubmed-meshheading:2525310-... | lld:pubmed |
pubmed-article:2525310 | pubmed:year | 1989 | lld:pubmed |
pubmed-article:2525310 | pubmed:articleTitle | Neurotensin modulates the binding characteristics of dopamine D2 receptors in rat striatal membranes also following treatment with toluene. | lld:pubmed |
pubmed-article:2525310 | pubmed:affiliation | Department of Histology, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
pubmed-article:2525310 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2525310 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2525310 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2525310 | lld:pubmed |