| pubmed-article:2524648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0041178 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0015295 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0079053 | lld:lifeskim |
| pubmed-article:2524648 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:2524648 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2524648 | pubmed:dateCreated | 1989-6-23 | lld:pubmed |
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| pubmed-article:2524648 | pubmed:abstractText | Structural analysis of the 5' end of the human c-fms gene revealed that a large intron of about 25 kilobases separates an upstream noncoding exon (exon 1) from the signal peptide-containing exon (exon 2). Northern (RNA) blot analysis, S1 nuclease mapping, and primer extensions showed that exon 1 is transcribed in placenta but not in cells of the monocytic lineage. This is due to the differential usage of promoters, separated by approximately 25 kilobases, in a cell-specific manner. One major c-fms transcript was observed in U-937 cells, whereas multiple initiation sites for transcription appeared to be utilized in placental cells. Nucleotide sequence comparisons showed that the 3' end of the human platelet-derived growth factor receptor gene lies approximately 350 base pairs upstream of the major initiation sites for c-fms transcription in placental trophoblasts. | lld:pubmed |
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| pubmed-article:2524648 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2524648 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2524648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2524648 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2524648 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2524648 | pubmed:author | pubmed-author:VermaI MIM | lld:pubmed |
| pubmed-article:2524648 | pubmed:author | pubmed-author:VisvaderJJ | lld:pubmed |
| pubmed-article:2524648 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2524648 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2524648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2524648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2524648 | pubmed:pagination | 1336-41 | lld:pubmed |
| pubmed-article:2524648 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:2524648 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2524648 | pubmed:articleTitle | Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes. | lld:pubmed |
| pubmed-article:2524648 | pubmed:affiliation | Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138. | lld:pubmed |
| pubmed-article:2524648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2524648 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2524648 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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