| pubmed-article:2523952 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2523952 | lifeskim:mentions | umls-concept:C0020517 | lld:lifeskim |
| pubmed-article:2523952 | lifeskim:mentions | umls-concept:C0023343 | lld:lifeskim |
| pubmed-article:2523952 | lifeskim:mentions | umls-concept:C0020522 | lld:lifeskim |
| pubmed-article:2523952 | lifeskim:mentions | umls-concept:C0162788 | lld:lifeskim |
| pubmed-article:2523952 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2523952 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2523952 | pubmed:dateCreated | 1989-6-9 | lld:pubmed |
| pubmed-article:2523952 | pubmed:abstractText | Analysis of tissue lesions of the major reactional states of leprosy was undertaken to study the immune mechanisms underlying regulation of cell-mediated immunity and delayed-type hypersensitivity (DTH) in man. In situ hybridization hybridization of reversal reaction biopsy specimens for INF-gamma mRNA expression revealed a 10-fold increase in specific mRNA-containing cells over that observed in unresponsive lepromatous patients. Expression of huHF serine esterase, a marker for T cytotoxic cells, were fourfold increased in reversal reaction and tuberculoid lesions above that detected in unresponsive lepromatous individuals. Immunohistology of reversal reactions confirmed a selective increase of Th and T cytotoxic cells in the cellular immune response. Of interest, the microanatomic location of these serine esterase mRNA-containing cells was identical to the distribution of CD4+ cells. Analysis of erythema nodosum leprosum (ENL) lesions revealed differences in the underlying immune processes in comparison with reversal reaction lesions. Although phenotypic Th cells predominated in ENL lesions, IFN-gamma and serine esterase gene expression were markedly reduced. We suggest that reversal reactions represent a hyperimmune DTH response characterized by a selective increase of CD4+ IFN-gamma producing cells and T cytotoxic cells, which result in the clearing of bacilli and concomitant tissue damage. In contrast, ENL reactions may be viewed as a transient diminution of Ts cells and activity leading to a partial and transient augmentation in cell-mediated immunity, perhaps sufficient to result in antibody and immune complex formation, but insufficient to clear bacilli from lesions. | lld:pubmed |
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| pubmed-article:2523952 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2523952 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2523952 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2523952 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2523952 | pubmed:month | May | lld:pubmed |
| pubmed-article:2523952 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:ChaoKK | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:BloomB RBR | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:WeissmanI LIL | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:KaplanGG | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:SHOT TTT | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:YoungS MSM | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:MuellerCC | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:CooperC LCL | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:PirmezCC | lld:pubmed |
| pubmed-article:2523952 | pubmed:author | pubmed-author:SinchaisriT... | lld:pubmed |
| pubmed-article:2523952 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2523952 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2523952 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:2523952 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2523952 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2523952 | pubmed:pagination | 1565-81 | lld:pubmed |
| pubmed-article:2523952 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2523952 | pubmed:meshHeading | pubmed-meshheading:2523952-... | lld:pubmed |
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| pubmed-article:2523952 | pubmed:meshHeading | pubmed-meshheading:2523952-... | lld:pubmed |
| pubmed-article:2523952 | pubmed:meshHeading | pubmed-meshheading:2523952-... | lld:pubmed |
| pubmed-article:2523952 | pubmed:meshHeading | pubmed-meshheading:2523952-... | lld:pubmed |
| pubmed-article:2523952 | pubmed:meshHeading | pubmed-meshheading:2523952-... | lld:pubmed |
| pubmed-article:2523952 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2523952 | pubmed:articleTitle | Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization. | lld:pubmed |
| pubmed-article:2523952 | pubmed:affiliation | Department of Pathology, University of Southern California, School of Medicine, Los Angeles 90033. | lld:pubmed |
| pubmed-article:2523952 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2523952 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2523952 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
