| pubmed-article:2510722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:2510722 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:2510722 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2510722 | pubmed:dateCreated | 1989-12-11 | lld:pubmed |
| pubmed-article:2510722 | pubmed:abstractText | This study examined the influence of lowered arterial levels of L-arginine on endothelium-dependent relaxation of isolated rings of bovine pulmonary artery. Incubation of arterial rings under tension for 24 hr in oxygenated Krebs bicarbonate solution at 37 degrees C resulted in the development of marked or complete tolerance to A23187 (calcium ionophore)- and acetylcholine-elicited relaxation. Relaxant responses to nitric oxide were unaffected. Addition of L-arginine did not relax control rings but did elicit marked endothelium-dependent relaxation of tolerant rings that was inhibited by oxyhemoglobin or methylene blue. L-Arginine also restored acetylcholine-elicited relaxation. Inclusion of L-canavanine in the 24 hr incubations protected against the development of tolerance. The tissue concentration of arginine was 3-fold lower in tolerant than control arterial rings and L-canavanine restored arterial arginine levels to control values. Therefore, depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. | lld:pubmed |
| pubmed-article:2510722 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510722 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2510722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510722 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2510722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2510722 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2510722 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2510722 | pubmed:author | pubmed-author:IgnarroL JLJ | lld:pubmed |
| pubmed-article:2510722 | pubmed:author | pubmed-author:BushP APA | lld:pubmed |
| pubmed-article:2510722 | pubmed:author | pubmed-author:GoldM EME | lld:pubmed |
| pubmed-article:2510722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2510722 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:2510722 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:2510722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2510722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2510722 | pubmed:pagination | 714-21 | lld:pubmed |
| pubmed-article:2510722 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2510722 | pubmed:meshHeading | pubmed-meshheading:2510722-... | lld:pubmed |
| pubmed-article:2510722 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2510722 | pubmed:articleTitle | Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. | lld:pubmed |
| pubmed-article:2510722 | pubmed:affiliation | Department of Pharmacology, UCLA School of Medicine Center for Health Sciences 90024. | lld:pubmed |
| pubmed-article:2510722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2510722 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2510722 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2510722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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