| pubmed-article:2500664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0222677 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:2500664 | lifeskim:mentions | umls-concept:C2346661 | lld:lifeskim |
| pubmed-article:2500664 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:2500664 | pubmed:dateCreated | 1989-8-10 | lld:pubmed |
| pubmed-article:2500664 | pubmed:abstractText | Lead (Pb) has been shown to perturb Ca-mediated cellular processes. However, to date, a direct effect of Pb on intracellular free Ca2+ concentration ([Ca2+]i) has not been demonstrated. 19F NMR in combination with 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid (5F-BAPTA) was used to simultaneously measure [Ca2+]i and intracellular free Pb2+ concentration ([Pb2+]i) in the rat osteoblastic bone cell line ROS 17/2.8. The basal concentration of [Ca2+]i in ROS 17/2.8 cells was measured to be 128 +/- 24 nM. Treatment with Pb2+ at 5 and 25 microM produced sustained 50% and 120% increases in [Ca2+]i, respectively, over a time course of 5 hr. At a medium Pb2+ concentration of 25 microM, the entry of Pb2+ into ROS 17/2.8 cells yielded measurable [Pb2+]i in cultured cells. Collectively, these findings advance the hypothesis that Pb toxicity is mediated, in part, through perturbations in [Ca2+]i. | lld:pubmed |
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| pubmed-article:2500664 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2500664 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2500664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2500664 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2500664 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2500664 | pubmed:author | pubmed-author:GuptaR KRK | lld:pubmed |
| pubmed-article:2500664 | pubmed:author | pubmed-author:RosenJ FJF | lld:pubmed |
| pubmed-article:2500664 | pubmed:author | pubmed-author:SchanneF AFA | lld:pubmed |
| pubmed-article:2500664 | pubmed:author | pubmed-author:DowdT LTL | lld:pubmed |
| pubmed-article:2500664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2500664 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2500664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2500664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2500664 | pubmed:pagination | 5133-5 | lld:pubmed |
| pubmed-article:2500664 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2500664 | pubmed:meshHeading | pubmed-meshheading:2500664-... | lld:pubmed |
| pubmed-article:2500664 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2500664 | pubmed:articleTitle | Lead increases free Ca2+ concentration in cultured osteoblastic bone cells: simultaneous detection of intracellular free Pb2+ by 19F NMR. | lld:pubmed |
| pubmed-article:2500664 | pubmed:affiliation | Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461. | lld:pubmed |
| pubmed-article:2500664 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2500664 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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