| pubmed-article:2500254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2500254 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2500254 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2500254 | pubmed:dateCreated | 1989-7-28 | lld:pubmed |
| pubmed-article:2500254 | pubmed:abstractText | The influence of recombinant (r) human tumor necrosis factor alpha (rTNF-alpha), r human interleukin 1 beta (rIL-1 beta), and r human interferon gamma (rIFN-gamma) on the production of interleukin 6 (IL-6) by human endothelial cells (HEC) was investigated. The addition of 1-100 U/ml of either rTNF-alpha or rIL-1 beta to cultures of HEC monolayers caused a dose-related increase in IL-6 production as detected after 24 hr of incubation. In contrast to rIL-1 beta and rTNF-alpha, the use of up to 1000 U/ml of rIFN-gamma caused only a moderate increase in IL-6 production. However, significantly greater quantities of IL-6 were produced by HEC monolayers subjected to 1000 U/ml of rIFN-gamma in combination with 1-100 U/ml of rTNF-alpha. Furthermore, the addition of graded concentrations of human transforming growth factor beta (TGF-beta) to cultures resulted in a dose-related inhibition of rIL-1 beta- and rTNF-alpha-induced IL-6 production by HEC. The results demonstrate that rIL-1 beta and rTNF-alpha share the ability to stimulate HEC for production of IL-6 and indicate that TGF-beta may act as an immunosuppressive agent, at least partially, through its ability to inhibit the action of TNF-alpha and IL-1 on endothelial cells. | lld:pubmed |
| pubmed-article:2500254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2500254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2500254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2500254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2500254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2500254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2500254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2500254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2500254 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2500254 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2500254 | pubmed:author | pubmed-author:WaageAA | lld:pubmed |
| pubmed-article:2500254 | pubmed:author | pubmed-author:ShalabyM RMR | lld:pubmed |
| pubmed-article:2500254 | pubmed:author | pubmed-author:EspevikTT | lld:pubmed |
| pubmed-article:2500254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2500254 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:2500254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2500254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2500254 | pubmed:pagination | 372-82 | lld:pubmed |
| pubmed-article:2500254 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2500254 | pubmed:meshHeading | pubmed-meshheading:2500254-... | lld:pubmed |
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| pubmed-article:2500254 | pubmed:meshHeading | pubmed-meshheading:2500254-... | lld:pubmed |
| pubmed-article:2500254 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2500254 | pubmed:articleTitle | Cytokine regulation of interleukin 6 production by human endothelial cells. | lld:pubmed |
| pubmed-article:2500254 | pubmed:affiliation | Institute of Cancer Research, University of Trondheim, Norway. | lld:pubmed |
| pubmed-article:2500254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2500254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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