| pubmed-article:2493978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C0001734 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C1160466 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C0006506 | lld:lifeskim |
| pubmed-article:2493978 | lifeskim:mentions | umls-concept:C1550147 | lld:lifeskim |
| pubmed-article:2493978 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2493978 | pubmed:dateCreated | 1989-4-26 | lld:pubmed |
| pubmed-article:2493978 | pubmed:abstractText | The effect of 2(3)-tert-butyl-4-hydroxyanisole (BHA) pretreatment of rats on both aflatoxin B1 (AFB1)-DNA binding and AFB1-glutathione has been examined with isolated hepatocytes and in intact rats. Young male F344 rats were fed AIN-76A diet with or without 0.75% BHA for 2 weeks. Even though there were no significant differences in either cytochrome P-450 or reduced glutathione contents, there were marked differences in AFB1 metabolism in isolated hepatocytes from these two groups. Thus, at the 33 nM AFB1 level, AFB1-DNA binding was 3-fold higher in control compared to BHA-treated hepatocytes whereas AFB1-glutathione conjugation was 5-fold higher in treated compared to controls. Even at higher AFB1 concentrations (2 and 10 microM), DNA binding was 4-6-fold higher in controls whereas thiol conjugation was 5-9-fold higher in treated compared to control hepatocytes. Addition of 0.5-1.0 mM diethylmaleate did not have any significant effect in control hepatocytes whereas its presence produced about 70-100% increase in DNA binding with 65-80% inhibition of thiol conjugation in treated hepatocytes. Addition of 1 mM styrene oxide caused 75-100% and 4-8-fold increase in AFB1-DNA binding in control and treated hepatocytes, respectively, with corresponding decreases in thiol conjugation. In intact rats, BHA treatment reduced hepatic AFB1-DNA binding to 15% of controls with concomitant increase in biliary excretion of AFB1-reduced glutathione conjugate. It appears that the induced cytosolic GSH S-transferases after BHA treatment of rats play a significant role in inhibiting hepatic AFB1-DNA binding and AFB1 hepatocarcinogenesis presumably by inactivation of the reactive AFB1-epoxide. | lld:pubmed |
| pubmed-article:2493978 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2493978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2493978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2493978 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2493978 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:2493978 | pubmed:author | pubmed-author:TsujiKK | lld:pubmed |
| pubmed-article:2493978 | pubmed:author | pubmed-author:LotlikarP DPD | lld:pubmed |
| pubmed-article:2493978 | pubmed:author | pubmed-author:GopalanPP | lld:pubmed |
| pubmed-article:2493978 | pubmed:author | pubmed-author:KtoYY | lld:pubmed |
| pubmed-article:2493978 | pubmed:author | pubmed-author:JheeE CEC | lld:pubmed |
| pubmed-article:2493978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2493978 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2493978 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:2493978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2493978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2493978 | pubmed:pagination | 1357-60 | lld:pubmed |
| pubmed-article:2493978 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:meshHeading | pubmed-meshheading:2493978-... | lld:pubmed |
| pubmed-article:2493978 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2493978 | pubmed:articleTitle | Effect of butylated hydroxyanisole pretreatment on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation in isolated hepatocytes from rats. | lld:pubmed |
| pubmed-article:2493978 | pubmed:affiliation | Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140. | lld:pubmed |
| pubmed-article:2493978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2493978 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2493978 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2493978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
