| pubmed-article:2483920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2483920 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2483920 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2483920 | pubmed:dateCreated | 1990-6-6 | lld:pubmed |
| pubmed-article:2483920 | pubmed:abstractText | The expression of the lymphokines GM-CSF and Multi-CSF (IL-3) has been studied in three IL-2-dependent CD4+ T lymphocyte clones. By contrast with the widely held view that lymphokine genes are coordinately expressed, the present study revealed a marked preference for GM-CSF compared with Multi-CSF expression. Preferential expression of GM-CSF was evident in a number of situations: early after stimulation via the T cell antigen receptor; in a proportion of low-producing cells of a clone; and in response to IL-2. There was a clear hierarchy of the three clones studied, each being ranked in the same order in all situations, suggesting that a common mechanism underlies each phenomenon. The possibility that the GM-CSF gene is responsive to lower doses of intercellular signal than the Multi-CSF gene was rendered unlikely, since in only one clone was GM-CSF preferentially expressed at low doses of stimulus. Since GM-CSF expression occurred more rapidly after stimulation, the possibility that Multi-CSF expression is dependent upon that of GM-CSF was considered. However, GM-CSF production was neither necessary nor sufficient for Multi-CSF expression: A retroviral construct expressing a GM-CSF cDNA was introduced into one of the clones, leading to constitutive GM-CSF expression, but Multi-CSF expression was not induced. The possibility is discussed that Multi-CSF expression is dependent on transcriptional activation of the GM-CSF locus and that positive feedback occurs between these two tightly linked genes at the chromosomal level. | lld:pubmed |
| pubmed-article:2483920 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2483920 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2483920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2483920 | pubmed:issn | 0897-7194 | lld:pubmed |
| pubmed-article:2483920 | pubmed:author | pubmed-author:KelsoAA | lld:pubmed |
| pubmed-article:2483920 | pubmed:author | pubmed-author:GoughN MNM | lld:pubmed |
| pubmed-article:2483920 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2483920 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2483920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2483920 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2483920 | pubmed:pagination | 287-98 | lld:pubmed |
| pubmed-article:2483920 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
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| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:meshHeading | pubmed-meshheading:2483920-... | lld:pubmed |
| pubmed-article:2483920 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2483920 | pubmed:articleTitle | GM-CSF expression is preferential to multi-CSF (IL-3) expression in murine T lymphocyte clones. | lld:pubmed |
| pubmed-article:2483920 | pubmed:affiliation | Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia. | lld:pubmed |
| pubmed-article:2483920 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2483920 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2483920 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2483920 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2483920 | lld:pubmed |
