| pubmed-article:2476238 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0699789 | lld:lifeskim |
| pubmed-article:2476238 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:2476238 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2476238 | pubmed:dateCreated | 1989-10-24 | lld:pubmed |
| pubmed-article:2476238 | pubmed:abstractText | Transgenic mice expressing a T cell receptor heterodimer specific for a fragment of pigeon cytochrome c plus an MHC class II molecule (I-Ek) have been made. We find that H-2k alpha beta transgenic mice have an overall increase in the number of T cells and express a 10-fold higher fraction of cytochrome c-reactive cells than H-2b mice. Surface staining of thymocytes indicates that in H-2b mice, T cell development is arrested at an intermediate stage of differentiation (CD4+8+, CD310). Analyses of mice carrying these T cell receptor genes and MHC class II I-E alpha constructs indicate that his developmental block can be reversed in H-2b mice by I-E expression on cortical epithelial cells of the thymus. These data suggest that a direct T cell receptor-MHC interaction occurs in the thymus in the absence of nominal antigen and results in the enhanced export of T cells, consistent with the concept of "positive selection". | lld:pubmed |
| pubmed-article:2476238 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2476238 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476238 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2476238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2476238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476238 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2476238 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2476238 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:DavisM MMM | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:BenoistCC | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:BergL JLJ | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:PullenA MAM | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:PORTEOUSDD | lld:pubmed |
| pubmed-article:2476238 | pubmed:author | pubmed-author:MathisDD | lld:pubmed |
| pubmed-article:2476238 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2476238 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:2476238 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2476238 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2476238 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2476238 | pubmed:pagination | 1035-46 | lld:pubmed |
| pubmed-article:2476238 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2476238 | pubmed:meshHeading | pubmed-meshheading:2476238-... | lld:pubmed |
| pubmed-article:2476238 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2476238 | pubmed:articleTitle | Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. | lld:pubmed |
| pubmed-article:2476238 | pubmed:affiliation | Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305. | lld:pubmed |
| pubmed-article:2476238 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2476238 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2476238 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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