| pubmed-article:2476095 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2476095 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:2476095 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:2476095 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2476095 | lifeskim:mentions | umls-concept:C2348693 | lld:lifeskim |
| pubmed-article:2476095 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2476095 | pubmed:dateCreated | 1989-10-12 | lld:pubmed |
| pubmed-article:2476095 | pubmed:abstractText | The introduction of a double bond at carbons 6 and 7 (6-dehydro-derivatives) of deoxycorticosterone acetate (DOCA), cortisol-21-acetate, 9 alpha-fluorocortisol-21-acetate (9 alpha-F-C-ac) and aldosterone-21-acetate substantially reduces affinity for Type II receptors but not for Type I receptors. Such a modification changes the effect of these steroids on urinary excretion of Na+ and K+. 6-Dehydro-derivatives will thus bind preferentially to receptor Type I inducing the retention of sodium and compete with mineralocorticoids for such receptors. The increase in both natriuresis and kaliuresis when corticosteroids and their 6-dehydro-derivatives are administered together may be interpreted as evidence for a Type II receptor mediation of those ion fluxes. The ionic changes are not mediated by the (Na+ + K+)-ATPase system. The fluoration at 9 and the dehydrogenation at C9C11 of DOCA result in a strong increase of binding to Type I receptor and of sodium retention. | lld:pubmed |
| pubmed-article:2476095 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2476095 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2476095 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2476095 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2476095 | pubmed:issn | 0003-9799 | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:GenardPP | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:Palem-VliersM... | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:HachaRR | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:KrzesinskiJ... | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:ChristiaensJ... | lld:pubmed |
| pubmed-article:2476095 | pubmed:author | pubmed-author:Lomba... | lld:pubmed |
| pubmed-article:2476095 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2476095 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:2476095 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2476095 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2476095 | pubmed:pagination | 175-83 | lld:pubmed |
| pubmed-article:2476095 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
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| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:meshHeading | pubmed-meshheading:2476095-... | lld:pubmed |
| pubmed-article:2476095 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2476095 | pubmed:articleTitle | Effect of various 6-dehydro-corticosteroids, 9, 11-dehydro-DOCA and 9 alpha-fluoro-DOCA on the fluxes of sodium and potassium. | lld:pubmed |
| pubmed-article:2476095 | pubmed:affiliation | Institut de Chimie; CHU, Université de Liège. | lld:pubmed |
| pubmed-article:2476095 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2476095 | pubmed:publicationType | Comparative Study | lld:pubmed |
