Linked Life Data

2475209

Source:http://linkedlifedata.com/resource/pubmed/id/2475209

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:2475209rdf:typepubmed:Citationlld:pubmed
pubmed-article:2475209lifeskim:mentionsumls-concept:C0025914lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0007776lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0014264lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0020361lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0041249lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0072879lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0442805lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0205373lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C1550605lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0456205lld:lifeskim
pubmed-article:2475209lifeskim:mentionsumls-concept:C0047472lld:lifeskim
pubmed-article:2475209pubmed:issue1lld:pubmed
pubmed-article:2475209pubmed:dateCreated1989-9-22lld:pubmed
pubmed-article:2475209pubmed:abstractTextSystemic infections and injection of endotoxin are known to increase L-tryptophan release from skeletal muscle and increase systemic L-tryptophan catabolism through the kynurenine pathway. To investigate the effects of systemically administered endotoxin on brain L-tryptophan metabolites. C57BL6/6NCR mice were given an intraperitoneal injection of 10 micrograms of lipopolysaccharide from Salmonella abortus equii and samples of serum and cerebral cortex collected. After 9 h, serum L-tryptophan concentration was decreased by 51%. At 9 h and 24 h, increases in L-tryptophan metabolites in cerebral cortex were: L-tryptophan, 42% and 39%; 5-hydroxyindoleacetic acid, 38% and 67%; 3-hydroxykynurenine, 235% and 381%; and quinolinic acid, 76% and 306%. Cortical quinolinic acid concentration was still elevated at 48 h (88%) and 72 h (79%) after lipopolysaccharide. No significant changes in cortical serotonin concentrations were found at the time points examined. When L-tryptophan (0.37 mmol/kg) was administered systemically to either normal or lipopolysaccharide-treated mice, increases in cortical L-tryptophan, serotonin, 5-hydroxyindoleacetic acid and 3-hydroxykynurenine concentrations were largest in mice treated with both lipopolysaccharide and L-tryptophan. These results suggest that disturbances in L-tryptophan metabolism that follow systemic endotoxin administration extend to the central nervous system. The consequences of these changes in L-tryptophan metabolites remain to be determined.lld:pubmed
pubmed-article:2475209pubmed:languageenglld:pubmed
pubmed-article:2475209pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:citationSubsetIMlld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2475209pubmed:statusMEDLINElld:pubmed
pubmed-article:2475209pubmed:monthJullld:pubmed
pubmed-article:2475209pubmed:issn0006-8993lld:pubmed
pubmed-article:2475209pubmed:authorpubmed-author:MarkeyS PSPlld:pubmed
pubmed-article:2475209pubmed:authorpubmed-author:HeyesM PMPlld:pubmed
pubmed-article:2475209pubmed:authorpubmed-author:QuearryB JBJlld:pubmed
pubmed-article:2475209pubmed:issnTypePrintlld:pubmed
pubmed-article:2475209pubmed:day3lld:pubmed
pubmed-article:2475209pubmed:volume491lld:pubmed
pubmed-article:2475209pubmed:ownerNLMlld:pubmed
pubmed-article:2475209pubmed:authorsCompleteYlld:pubmed
pubmed-article:2475209pubmed:pagination173-9lld:pubmed
pubmed-article:2475209pubmed:dateRevised2003-11-14lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:meshHeadingpubmed-meshheading:2475209-...lld:pubmed
pubmed-article:2475209pubmed:year1989lld:pubmed
pubmed-article:2475209pubmed:articleTitleSystemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.lld:pubmed
pubmed-article:2475209pubmed:affiliationSection on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892.lld:pubmed
pubmed-article:2475209pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2475209lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2475209lld:pubmed