| pubmed-article:2474864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0035273 | lld:lifeskim |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2474864 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:2474864 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2474864 | pubmed:dateCreated | 1989-9-8 | lld:pubmed |
| pubmed-article:2474864 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:abstractText | In response to specific stresses, such as a heat pulse or the sequence of hypoxia-reoxygenation, each isolated cell (prokaryotic and eukaryotic) that has been studied characteristically alters gene expression to synthesize a set of proteins (heat-shock proteins) that are important for intracellular homeostasis. To determine whether a corresponding response occurs within parenchymal cells in vivo when subjected to the complex stress of circulatory shock, liver biopsy specimens were obtained from a swine model of cardiogenic shock before and after shock/resuscitation. With use of complementary DNA prepared from post-shock/resuscitation messenger RNA, a library was constructed and screened for differential gene expression. Of 32/4000 clones initially screened as positive for induction after shock/resuscitation, six were confirmed positive by Northern blot analysis. The nucleotide sequences of two of these six have been determined, and one has been unambiguously identified as metallothionein. | lld:pubmed |
| pubmed-article:2474864 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2474864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2474864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2474864 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2474864 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2474864 | pubmed:issn | 0039-6060 | lld:pubmed |
| pubmed-article:2474864 | pubmed:author | pubmed-author:PorterJ MJM | lld:pubmed |
| pubmed-article:2474864 | pubmed:author | pubmed-author:BuchmanT GTG | lld:pubmed |
| pubmed-article:2474864 | pubmed:author | pubmed-author:BulkleyG BGB | lld:pubmed |
| pubmed-article:2474864 | pubmed:author | pubmed-author:CardoV AVAJr | lld:pubmed |
| pubmed-article:2474864 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2474864 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:2474864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2474864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2474864 | pubmed:pagination | 283-90; discussion 290-1 | lld:pubmed |
| pubmed-article:2474864 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:meshHeading | pubmed-meshheading:2474864-... | lld:pubmed |
| pubmed-article:2474864 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2474864 | pubmed:articleTitle | Change in hepatic gene expression after shock/resuscitation. | lld:pubmed |
| pubmed-article:2474864 | pubmed:affiliation | Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Md. | lld:pubmed |
| pubmed-article:2474864 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2474864 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2474864 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:397417 | entrezgene:pubmed | pubmed-article:2474864 | lld:entrezgene |
