| pubmed-article:2473839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2473839 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:2473839 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:2473839 | lifeskim:mentions | umls-concept:C1332721 | lld:lifeskim |
| pubmed-article:2473839 | lifeskim:mentions | umls-concept:C1660149 | lld:lifeskim |
| pubmed-article:2473839 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2473839 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2473839 | pubmed:dateCreated | 1989-8-29 | lld:pubmed |
| pubmed-article:2473839 | pubmed:abstractText | Tyrosine phosphorylation of cdc2 is regulated in the cell cycle of mouse 3T3 fibroblasts. Phosphotyrosine in cdc2 is detectable at the onset of DNA synthesis and becomes maximal in the G2 phase of the cell cycle. Quantitative tyrosine dephosphorylation of cdc2 occurs during entry into mitosis and no phosphotyrosine is detected during the G1 phase of the cell cycle. While increasing tyrosine phosphorylation of cdc2 correlates with the formation of a cdc2/p62 complex, the tyrosine phosphorylated cdc2 is inactive as a histone H1 kinase. cdc2 is fully dephosphorylated in its most active mitotic form, yet specific tyrosine dephosphorylation of interphase cdc2 in vitro is insufficient to activate the kinase. In vivo inhibition of tyrosine dephosphorylation by exposure of cells to a phosphatase inhibitor is associated with G2 arrest, which is reversible upon the removal of the phosphatase inhibitor. Tyrosine dephosphorylation of cdc2 may be one of a number of obligatory steps in the mitotic activation of the kinase. | lld:pubmed |
| pubmed-article:2473839 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2473839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2473839 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2473839 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2473839 | pubmed:author | pubmed-author:BeachDD | lld:pubmed |
| pubmed-article:2473839 | pubmed:author | pubmed-author:WangJ YJY | lld:pubmed |
| pubmed-article:2473839 | pubmed:author | pubmed-author:DraettaGG | lld:pubmed |
| pubmed-article:2473839 | pubmed:author | pubmed-author:MorlaA OAO | lld:pubmed |
| pubmed-article:2473839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2473839 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:2473839 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2473839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2473839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2473839 | pubmed:pagination | 193-203 | lld:pubmed |
| pubmed-article:2473839 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:meshHeading | pubmed-meshheading:2473839-... | lld:pubmed |
| pubmed-article:2473839 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2473839 | pubmed:articleTitle | Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. | lld:pubmed |
| pubmed-article:2473839 | pubmed:affiliation | Department of Biology, University of California, La Jolla, San Diego 92093. | lld:pubmed |
| pubmed-article:2473839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2473839 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2473839 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:983 | entrezgene:pubmed | pubmed-article:2473839 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2473839 | lld:pubmed |
