| pubmed-article:2473838 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C0178453 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C0080054 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1424876 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:2473838 | lifeskim:mentions | umls-concept:C1743875 | lld:lifeskim |
| pubmed-article:2473838 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2473838 | pubmed:dateCreated | 1989-8-29 | lld:pubmed |
| pubmed-article:2473838 | pubmed:abstractText | It has been demonstrated that the Xenopus homolog of the fission yeast cdc2 protein is a component of M phase promoting factor (MPF). We show that the Xenopus cdc2 protein is phosphorylated on tyrosine in vivo, and that this tyrosine phosphorylation varies markedly with the stage of the cell cycle. Tyrosine phosphorylation is high during interphase (in Xenopus oocytes and activated eggs) but absent during M phase (in unfertilized eggs). In vitro activation of pre-MPF from Xenopus oocytes results in tyrosine dephosphorylation of the cdc2 protein and switching-on of its kinase activity. The product of the fission yeast suc1 gene (p13), which inhibits the entry into mitosis in Xenopus extracts, completely blocks tyrosine dephosphorylation and kinase activation. However, p13 has no effect on the activated form of the cdc2 kinase. These findings suggest that p13 controls the activation of the cdc2 kinase, and that tyrosine dephosphorylation is an important step in this process. | lld:pubmed |
| pubmed-article:2473838 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473838 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2473838 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473838 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2473838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2473838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2473838 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2473838 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2473838 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2473838 | pubmed:author | pubmed-author:NewportJ WJW | lld:pubmed |
| pubmed-article:2473838 | pubmed:author | pubmed-author:DunphyW GWG | lld:pubmed |
| pubmed-article:2473838 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2473838 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:2473838 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2473838 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2473838 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2473838 | pubmed:pagination | 181-91 | lld:pubmed |
| pubmed-article:2473838 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2473838 | pubmed:meshHeading | pubmed-meshheading:2473838-... | lld:pubmed |
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| pubmed-article:2473838 | pubmed:meshHeading | pubmed-meshheading:2473838-... | lld:pubmed |
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| pubmed-article:2473838 | pubmed:meshHeading | pubmed-meshheading:2473838-... | lld:pubmed |
| pubmed-article:2473838 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2473838 | pubmed:articleTitle | Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. | lld:pubmed |
| pubmed-article:2473838 | pubmed:affiliation | Department of Biology, University of California, San Diego, La Jolla 92093. | lld:pubmed |
| pubmed-article:2473838 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2473838 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2473838 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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