| pubmed-article:2471814 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C0034494 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C1325834 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C1552861 | lld:lifeskim |
| pubmed-article:2471814 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:2471814 | pubmed:dateCreated | 1989-7-24 | lld:pubmed |
| pubmed-article:2471814 | pubmed:abstractText | Human T cell clones were prepared from peripheral blood mononuclear cells from a vaccinated human donor and kept in culture in the presence of rabies virus antigen and growth factors. Phenotypic analysis of the T cell clones revealed expression of the CD3 and CD4 cell surface markers, but not of CD8, consistent with a phenotype of helper/inducer T cells. The rabies virus specificity of the T cell clones was established by virus-specific proliferation in response to the rabies virus Pitman-Moore strain (PM) produced in three different cell substrates. The clones also responded to the rabies virus strains Evelyn-Rokitnicki-Abelseth (ERA) and challenge virus standard (CVS), but not to the rabies virus-related Mokola and Duvenhage-6 virus strains. Proliferative responses of T cell clones required rabies virus antigen to be presented by autologous antigen-presenting cells in association with HLA class II molecules. When cultured with rabies virus antigen, but in the absence of growth factors, some of the T cell clones provided help for an antibody response of rabies virus immune B lymphocytes. Analysis of culture supernatant fluids showed that at least a part of this antibody response was directed against neutralizing antibody-inducing determinants of the viral glycoprotein. | lld:pubmed |
| pubmed-article:2471814 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2471814 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471814 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2471814 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2471814 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:OsterhausA... | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:BunschotenHH | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:UytdehaagF... | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:ClaassenI JIJ | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:KlapmutsR JRJ | lld:pubmed |
| pubmed-article:2471814 | pubmed:author | pubmed-author:ReyneveldS... | lld:pubmed |
| pubmed-article:2471814 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2471814 | pubmed:volume | 70 ( Pt 6) | lld:pubmed |
| pubmed-article:2471814 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2471814 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2471814 | pubmed:pagination | 1513-21 | lld:pubmed |
| pubmed-article:2471814 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:meshHeading | pubmed-meshheading:2471814-... | lld:pubmed |
| pubmed-article:2471814 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2471814 | pubmed:articleTitle | Rabies virus-specific human T cell clones provide help for an in vitro antibody response against neutralizing antibody-inducing determinants of the viral glycoprotein. | lld:pubmed |
| pubmed-article:2471814 | pubmed:affiliation | National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands. | lld:pubmed |
| pubmed-article:2471814 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2471814 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2471814 | lld:pubmed |
