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pubmed-article:2470599pubmed:abstractTextThe effects of gamma-preprotachykinin-(72-92)-peptide amide [gamma-PPT-(72-92)-NH2] on salivation in the rat were investigated and were compared with salivation responses elicited by a variety of other tachykinin and related peptides. On intravenous injection or continuous infusion, gamma-PPT-(72-92)-NH2, a naturally occurring N-terminally extended derivative of neurokinin A (NKA), potently stimulated salivation. The rank order of potency of peptides that stimulated salivation was: NPK greater than gamma-PPT-(72-92)-NH2 greater than substance P greater than NKA = Asp-Ala-NKA. Moreover, gamma-PPT-(72-92)-NH2, like NPK, potentiated the effects of substance P on salivary secretion. These results indicate that the actions of gamma-PPT-(72-92)-NH2 may be pharmacologically or physiologically relevant in the actions of tachykinin peptides.lld:pubmed
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pubmed-article:2470599pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2470599pubmed:articleTitlegamma-Preprotachykinin-(72-92)-peptide amide potentiates substance P-induced salivation.lld:pubmed
pubmed-article:2470599pubmed:affiliationDepartment of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.lld:pubmed
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pubmed-article:2470599pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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