| pubmed-article:2467294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2467294 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:2467294 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2467294 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2467294 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:2467294 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2467294 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2467294 | pubmed:dateCreated | 1989-4-28 | lld:pubmed |
| pubmed-article:2467294 | pubmed:abstractText | Immunization of rabbits with certain H1N1 influenza viruses, including the neurotropic strains NWS/33 and WSN/33 and the New Jersey/76 strain, resulted in the production of autoantibodies to a brain-specific protein of 37 kDa that is present in various species, including humans. Autoantibodies were produced to brain only; various other tissues tested were negative. These antibodies were not elicited by other influenza A or B viruses, including closely related recombinant strains, but were elicited by the isolated hemagglutinin of A/Bellamy/42 strain and by formaldehyde-fixed WSN virus--demonstrating that infection was not essential for the induction of autoantibodies. In histological studies, reaction with anti-viral antisera was specific to gray matter and was confined to sera that recognized the 37-kDa protein. Antibody binding was prominent in regions comprised of neuronal cell bodies in cellular layers of the dentate gyrus, hippocampus, cerebral cortex, and cerebellum and was undetectable in myelin-rich regions, such as the corpus callosum. The 37-kDa protein, therefore, appears to be a neuronal antigen. Antibodies directed against this protein may be involved in the pathogenesis of one or more of the neuropsychiatric disorders that occur after infection with influenza. | lld:pubmed |
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| pubmed-article:2467294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2467294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467294 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2467294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2467294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2467294 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2467294 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:PertC BCB | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:PaulS MSM | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:WebsterR GRG | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:HillJ MJM | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:OxfordJ SJS | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:MarkwellM AMA | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:KnightJ GJG | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:LaineVV | lld:pubmed |
| pubmed-article:2467294 | pubmed:author | pubmed-author:HarrisA GAG | lld:pubmed |
| pubmed-article:2467294 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2467294 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2467294 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2467294 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2467294 | pubmed:pagination | 1998-2002 | lld:pubmed |
| pubmed-article:2467294 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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