| pubmed-article:2467208 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0059553 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0271994 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0017033 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2467208 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2467208 | pubmed:issue | 6214 | lld:pubmed |
| pubmed-article:2467208 | pubmed:dateCreated | 1989-4-28 | lld:pubmed |
| pubmed-article:2467208 | pubmed:abstractText | In man, a shift from gamma- to beta-globin gene expression in erythroblasts underlies a switch from fetal to adult haemoglobin during development. In hereditary persistence of fetal haemoglobin (HPFH), inappropriately high gamma-globin expression in adult life is associated with deletions in the beta-globin cluster or with single-base changes upstream of the gamma-globin genes. To account for enhanced gamma-gene expression in HPFH of the non-deletion type, we tested the nuclear proteins of human erythroleukaemia cells that bind gamma-promoter sequences in vitro by correlating specific mutations in their binding sites with promoter activity. An erythroid-specific factor (GF-1) binds as a single molecule to the -195 to -170 region and contacts two TATCT(AGATA) motifs, but not the conserved octamer (ATGCAAAT) that separates them. We observe that a single change (at -175, T----C) found in HPFH leads to increased promoter activity only in erythroid cells. This effect is mediated by GF-1, the human counterpart of the chicken erythroid factor Eryf 1. The form of HPFH we studied here is an inherited disorder which can be ascribed to the action of a cell-specific DNA-binding factor on a mutant promoter. | lld:pubmed |
| pubmed-article:2467208 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2467208 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2467208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2467208 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2467208 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2467208 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2467208 | pubmed:author | pubmed-author:OrkinS HSH | lld:pubmed |
| pubmed-article:2467208 | pubmed:author | pubmed-author:TsaiS FSF | lld:pubmed |
| pubmed-article:2467208 | pubmed:author | pubmed-author:MartinD IDI | lld:pubmed |
| pubmed-article:2467208 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2467208 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:2467208 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:2467208 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2467208 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2467208 | pubmed:pagination | 435-8 | lld:pubmed |
| pubmed-article:2467208 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:meshHeading | pubmed-meshheading:2467208-... | lld:pubmed |
| pubmed-article:2467208 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2467208 | pubmed:articleTitle | Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. | lld:pubmed |
| pubmed-article:2467208 | pubmed:affiliation | Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:2467208 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2467208 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2467208 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2623 | entrezgene:pubmed | pubmed-article:2467208 | lld:entrezgene |
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