| pubmed-article:2463306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:2463306 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:2463306 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2463306 | pubmed:dateCreated | 1989-2-14 | lld:pubmed |
| pubmed-article:2463306 | pubmed:abstractText | We previously reported that idiotype (Id)-loss, stable somatic variants of a B cell hybrid, 2C3E1, are generated both in vitro and in vivo, after interaction of the Id-positive tumor cells with autologous Id-specific effector T cells. The present investigation was undertaken to elucidate further the nature and functional characteristics of the effector T cells. We report here that the idiotype-specific cells mediating the generation of Id- tumor variants are Thy1+ L3T4+ Lyt-2- cells, which respond to specific idiotypic stimulation by secreting IL-2 in vitro. No IL-2 is secreted in response to unrelated Ig or an Id/Ig-2C3E1 tumor variant. Furthermore, the Id-specific T cells exert strong suppressive effects on the expression of 2C3E1 Ig and the effects can be reversed by blocking the L3T4+ T cells with monoclonal anti-L3T4 antibody in vitro during the initial 3 days of co-culture. After 4 days, the T cell-mediated suppression of the 2C3E1-Id is irreversible. In addition to the in vitro studies we have determined that the administration of anti-L3T4 mAb to mice just before priming with idiotype-bearing tumor cells also abrogates the suppressive effects of the idiotype primed spleen cells on Ig expression of 2C3E1. To study the Id-specific effector T cells in more detail we have generated functional Id-specific L3T4+ T cell lines. These T cell lines have been shown to recapitulate the generation of Id- tumor variants that we observed with Id-primed spleen cells. It is concluded that L3T4+, Id-specific Ts cells are responsible for the generation of somatic variants of the B cell hybrid 2C3E1 and that the induction or selection of these variants progresses from a reversible phase to an irreversible phase. | lld:pubmed |
| pubmed-article:2463306 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2463306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2463306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2463306 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2463306 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2463306 | pubmed:author | pubmed-author:GhoshS KSK | lld:pubmed |
| pubmed-article:2463306 | pubmed:author | pubmed-author:BankertR BRB | lld:pubmed |
| pubmed-article:2463306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2463306 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2463306 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:2463306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2463306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2463306 | pubmed:pagination | 409-15 | lld:pubmed |
| pubmed-article:2463306 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
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| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
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| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:meshHeading | pubmed-meshheading:2463306-... | lld:pubmed |
| pubmed-article:2463306 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2463306 | pubmed:articleTitle | Generation of somatic variants of a B cell hybrid mediated by a non-cytolytic L3T4+ idiotype-specific T cell. | lld:pubmed |
| pubmed-article:2463306 | pubmed:affiliation | Department of Molecular Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263. | lld:pubmed |
| pubmed-article:2463306 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2463306 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2463306 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2463306 | lld:pubmed |
