| pubmed-article:2463303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:2463303 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2463303 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2463303 | pubmed:dateCreated | 1989-2-14 | lld:pubmed |
| pubmed-article:2463303 | pubmed:abstractText | The present studies were carried out to characterize the influence of the T cell maturation environment on a repertoire of Th cells, T augmenting cells, and Ts cells, which were shown to construct a minimal regulatory circuit to regulate a helper function of class II-restricted Th cells. A repertoire of keyhole limpet hemocyanin-specific Th cells was influenced predominantly by I-A molecules of the T cell maturation environment, whereas a repertoire of T augmenting cells was determined by both I-A and I-E molecules. These repertoires were not influenced by the priming with Ag. A repertoire of Ts cell factor-producing Ts cells was not influenced by the T cell maturation environment, but rather was determined by the I-J haplotype of the APC utilized for priming with Ag. In contrast, a repertoire of novel cognate type Ts cells, which inhibit class II-restricted Th cell function in a restriction-restricted manner, was influenced by both I-A and I-E molecules of the T cell maturation environment. These results demonstrate the two distinct mechanisms for generating a T cell repertoire: a selection by class II molecules of the T cell maturation environment before the priming with foreign Ag and a selection by priming with APC and Ag. | lld:pubmed |
| pubmed-article:2463303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2463303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2463303 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2463303 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2463303 | pubmed:author | pubmed-author:BRUCEM AMA | lld:pubmed |
| pubmed-article:2463303 | pubmed:author | pubmed-author:TadaTT | lld:pubmed |
| pubmed-article:2463303 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2463303 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2463303 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:2463303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2463303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2463303 | pubmed:pagination | 365-73 | lld:pubmed |
| pubmed-article:2463303 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
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| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:meshHeading | pubmed-meshheading:2463303-... | lld:pubmed |
| pubmed-article:2463303 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2463303 | pubmed:articleTitle | Generation of T cell repertoire. Two distinct mechanisms for generation of T suppressor cells, T helper cells, and T augmenting cells. | lld:pubmed |
| pubmed-article:2463303 | pubmed:affiliation | Department of Immunology, Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:2463303 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2463303 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2463303 | lld:pubmed |
