| pubmed-article:2463025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0006684 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0747055 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2463025 | lifeskim:mentions | umls-concept:C0004855 | lld:lifeskim |
| pubmed-article:2463025 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2463025 | pubmed:dateCreated | 1989-2-21 | lld:pubmed |
| pubmed-article:2463025 | pubmed:abstractText | 1. Bay K 8644 (10(-8) to 10(-6) M) induced concentration-related contractions of the longitudinal muscle of the mouse distal colon. The maximal responses were enhanced and the EC50 was lowered in the presence of tetrodotoxin (TTX; 1.5 x 10(-7) M). The responses were not affected by atropine (10(-7) M), mepyramine (2.5 x 10(-7) M), methysergide (5 x 10(-7) M), propranolol (10(-6) M), phentolamine (10(-6) M) or naloxone (4 x 10(-7) M). By contrast, the contractile responses were inhibited by Ca2+ entry blockers (verapamil, nifedipine) and abolished in Ca2+-free EGTA solution. These observations indicate that the contractile effects of Bay K 8644 are dependent on its ability to promote Ca2+ influx. 2. At 10(-4) M, Bay K 8644 provoked a slow relaxation of the preparation. Moreover, from 10(-5) M, Bay K 8644 markedly reduced the contractile responses to ACh and K+ depolarization. These inhibitory effects were comparable with those produced by nifedipine. Such data suggest that, at high concentrations, Bay K 8644 could act in part as a dihydropyridine Ca2+ channel antagonist. 3. Bay K 8644 (10(-9) M) preferentially enhanced, while nifedipine (10(-10) to 10(-8) M) as well as verapamil (3 x 10(-9) to 10(-6) M) preferentially inhibited, the tonic component of the contractile response evoked by K+ depolarizing solution. This may indicate that different populations of voltage-sensitive Ca2+ channels are involved in the biphasic response to K+ depolarization. 4. The biphasic contractile activity induced by ACh was barely enhanced by Bay K 8644 (10-9M) and was less sensitive to Ca2+ entry blockers than the responses to KCl. These findings are discussed in terms of receptor-operated channels and mobilization of bound calcium. | lld:pubmed |
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| pubmed-article:2463025 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2463025 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2463025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2463025 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2463025 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2463025 | pubmed:author | pubmed-author:FontaineJJ | lld:pubmed |
| pubmed-article:2463025 | pubmed:author | pubmed-author:LebrunPP | lld:pubmed |
| pubmed-article:2463025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2463025 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:2463025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2463025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2463025 | pubmed:pagination | 1198-205 | lld:pubmed |
| pubmed-article:2463025 | pubmed:dateRevised | 2010-4-26 | lld:pubmed |
| pubmed-article:2463025 | pubmed:meshHeading | pubmed-meshheading:2463025-... | lld:pubmed |
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| pubmed-article:2463025 | pubmed:meshHeading | pubmed-meshheading:2463025-... | lld:pubmed |
| pubmed-article:2463025 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2463025 | pubmed:articleTitle | Pharmacological analysis of the effects of Bay K 8644 and organic calcium antagonists on the mouse isolated distal colon. | lld:pubmed |
| pubmed-article:2463025 | pubmed:affiliation | Free University of Brussels, Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Belgium. | lld:pubmed |
| pubmed-article:2463025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2463025 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2463025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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