pubmed-article:2462673 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0024530 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
pubmed-article:2462673 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
pubmed-article:2462673 | pubmed:issue | 6201 | lld:pubmed |
pubmed-article:2462673 | pubmed:dateCreated | 1989-2-1 | lld:pubmed |
pubmed-article:2462673 | pubmed:abstractText | An ideal vaccine should elicit a long lasting immune response against the natural parasite, both at the T- and B-cell level. The immune response should occur in all individuals and be directed against determinants that do not vary in the natural parasite population. A major problem in designing synthetic peptide vaccines is that T cells generally recognize peptide antigens only in association with one or a few of the many variants of major histocompatibility complex (MHC) antigens. During the characterization of epitopes of the malaria parasite Plasmodium falciparum that are recognized by human T cells, we analysed a sequence of the circumsporozoite protein, and found that synthetic peptides corresponding to this sequence are recognized by T cells in association with many different MHC class II molecules, both in mouse and in man. This region of the circumsporozoite protein is invariant in different parasite isolates. Peptides derived from this region should be capable of inducing T-cell responses in individuals of most HLA-DR types, and may represent good candidates for inclusion in an effective anti-malaria peptide vaccine. | lld:pubmed |
pubmed-article:2462673 | pubmed:language | eng | lld:pubmed |
pubmed-article:2462673 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2462673 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2462673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2462673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2462673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2462673 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2462673 | pubmed:issn | 0028-0836 | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:MatileHH | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:PinkJ RJR | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:DoranD MDM | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:GillessenDD | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:TrzeciakAA | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:SinigagliaFF | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:GuttingerMM | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:EtlingerHH | lld:pubmed |
pubmed-article:2462673 | pubmed:author | pubmed-author:KilgusJJ | lld:pubmed |
pubmed-article:2462673 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2462673 | pubmed:volume | 336 | lld:pubmed |
pubmed-article:2462673 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2462673 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2462673 | pubmed:pagination | 778-80 | lld:pubmed |
pubmed-article:2462673 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:meshHeading | pubmed-meshheading:2462673-... | lld:pubmed |
pubmed-article:2462673 | pubmed:articleTitle | A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. | lld:pubmed |
pubmed-article:2462673 | pubmed:affiliation | Central Research Units, F. Hoffmann-La Roche & Co. Ltd, Basel, Switzerland. | lld:pubmed |
pubmed-article:2462673 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2462673 | lld:pubmed |