| pubmed-article:2458484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C0162807 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C0035380 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:2458484 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:2458484 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2458484 | pubmed:dateCreated | 1988-10-19 | lld:pubmed |
| pubmed-article:2458484 | pubmed:abstractText | Genetic evidence is presented which suggests the existence of an important structural element in the 5' noncoding region of avian retrovirus RNA. The proposed structure, which we term the U5-leader stem, is composed of sequences in the middle of U5 and in the leader, flanking the primer-binding site. U5 and leader mutations which would disrupt this structure caused a partial replication defect. However, nucleotide substitutions in the leader, which would structurally compensate for a U5 deletion mutation, restored normal replication. Analysis of replication intermediates of viruses with the above mutations suggests that the U5-leader stem is required for efficient DNA synthesis in vivo and for initiation of DNA synthesis from the tRNA(Trp) primer in melittin-activated virions. However, this structure does not appear to be required for binding of the tRNA(Trp) primer to viral RNA. These results support a role for the U5-leader stem structure, independent of its primary sequence, in the initiation of retroviral replication. | lld:pubmed |
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| pubmed-article:2458484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2458484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2458484 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2458484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2458484 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2458484 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:2458484 | pubmed:author | pubmed-author:LeisJJ | lld:pubmed |
| pubmed-article:2458484 | pubmed:author | pubmed-author:CobrinikDD | lld:pubmed |
| pubmed-article:2458484 | pubmed:author | pubmed-author:SoskeyLL | lld:pubmed |
| pubmed-article:2458484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2458484 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2458484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2458484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2458484 | pubmed:pagination | 3622-30 | lld:pubmed |
| pubmed-article:2458484 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2458484 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2458484 | pubmed:articleTitle | A retroviral RNA secondary structure required for efficient initiation of reverse transcription. | lld:pubmed |
| pubmed-article:2458484 | pubmed:affiliation | Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106. | lld:pubmed |
| pubmed-article:2458484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2458484 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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