| pubmed-article:2456577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2456577 | lifeskim:mentions | umls-concept:C0024535 | lld:lifeskim |
| pubmed-article:2456577 | lifeskim:mentions | umls-concept:C0206255 | lld:lifeskim |
| pubmed-article:2456577 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
| pubmed-article:2456577 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:2456577 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:2456577 | pubmed:dateCreated | 1988-9-7 | lld:pubmed |
| pubmed-article:2456577 | pubmed:abstractText | Immunogens included in a subunit vaccine should contain both B- and T-cell-activating sites to ensure anamnestic responses following reinfection after vaccination as well as antibody-independent cellular immunity. The Plasmodium falciparum antigen Pf155/RESA, a major candidate for a vaccine against the asexual blood stages of this malaria parasite, was investigated for T-cell epitopes in its C-terminal amino acid repeat region, a region known to be conserved in different P. falciparum strains. It was found to contain several related sequences that activated T cells from humans primed to P. falciparum by natural exposure, to proliferation, and/or interferon-gamma release in vitro. T cells from approximately half of the donor group investigated responded to the intact protein, and 65% of these responders also responded to short synthetic peptides, probably representing a small number of partly overlapping T-cell epitopes. Thus, sequences from the C terminus of Pf155 may be suitable constituents of a P. falciparum subunit vaccine and also provide a basis for epitope-specific epidemiological studies relating cellular immune responses in vitro to clinical immunity and P. falciparum endemicity. | lld:pubmed |
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| pubmed-article:2456577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2456577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2456577 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2456577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2456577 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2456577 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:PerlmannPP | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:PerlmannHH | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:AnderssonGG | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:PetersenEE | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:BjörkmanAA | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:Troye-Blomber... | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:HöghBB | lld:pubmed |
| pubmed-article:2456577 | pubmed:author | pubmed-author:KabilanLL | lld:pubmed |
| pubmed-article:2456577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2456577 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2456577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2456577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2456577 | pubmed:pagination | 5659-63 | lld:pubmed |
| pubmed-article:2456577 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2456577 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2456577 | pubmed:articleTitle | T-cell epitopes in Pf155/RESA, a major candidate for a Plasmodium falciparum malaria vaccine. | lld:pubmed |
| pubmed-article:2456577 | pubmed:affiliation | Department of Immunology, University of Stockholm, Sweden. | lld:pubmed |
| pubmed-article:2456577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2456577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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