| pubmed-article:2454932 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0682523 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0016055 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2454932 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2454932 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2454932 | pubmed:dateCreated | 1988-8-10 | lld:pubmed |
| pubmed-article:2454932 | pubmed:abstractText | The regulation of fibronectin (FN) biosynthesis by dexamethasone (a synthetic glucocorticoid), forskolin (an activator of adenylate cyclase), and transforming growth factor beta (TGF-beta) was examined in six human cell lines. Dexamethasone treatment produced the largest increase in FN biosynthesis in the fibrosarcoma cell line, HT-1080 (approximately 45-fold). This seems to result from a dexamethasone-mediated increase in FN mRNA stability which increases the message half-life from approximately 11 to 26 h. The relative instability of FN mRNA in the fibrosarcoma (t1/2 11 h) compared to normal fibroblasts (70 h) appears to result from the particular transformed phenotype of the HT-1080 cells. Forskolin and TGF-beta increase the rate of FN gene transcription in most of the cell lines. These effects (four- to six-fold) occur rapidly and do not require protein synthesis in the responsive cell lines which include normal fibroblasts. However, in the fibrosarcoma (HT-1080), a surprisingly large induction (20-30-fold) is observed and this induction is different from that in the normal fibroblasts and the other cell lines in that both protein synthesis and a lag period are required. Synergism is seen with dexamethasone and either forskolin or TGF-beta in HT-1080 cells increasing the rate of FN biosynthesis approximately 200-fold to a level similar to normal fibroblasts. This seems to result from a combination of FN mRNA stabilization (dexamethasone) and increased transcription (forskolin and TGF-beta). | lld:pubmed |
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| pubmed-article:2454932 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2454932 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2454932 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2454932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2454932 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2454932 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2454932 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:2454932 | pubmed:author | pubmed-author:BourgeoisSS | lld:pubmed |
| pubmed-article:2454932 | pubmed:author | pubmed-author:DeanD CDC | lld:pubmed |
| pubmed-article:2454932 | pubmed:author | pubmed-author:NewbyR FRF | lld:pubmed |
| pubmed-article:2454932 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2454932 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:2454932 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2454932 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2454932 | pubmed:pagination | 2159-70 | lld:pubmed |
| pubmed-article:2454932 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2454932 | pubmed:meshHeading | pubmed-meshheading:2454932-... | lld:pubmed |
| pubmed-article:2454932 | pubmed:meshHeading | pubmed-meshheading:2454932-... | lld:pubmed |
| pubmed-article:2454932 | pubmed:meshHeading | pubmed-meshheading:2454932-... | lld:pubmed |
