| pubmed-article:2453262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C0008051 | lld:lifeskim |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C0005497 | lld:lifeskim |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C0039185 | lld:lifeskim |
| pubmed-article:2453262 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2453262 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2453262 | pubmed:dateCreated | 1988-7-11 | lld:pubmed |
| pubmed-article:2453262 | pubmed:abstractText | Two experiments were conducted to determine the effect of T-2 toxin on brain biogenic monoamines and their metabolites. Male rats (180 g) and cockerels (28 day, 300 g) were orally dosed with T-2 toxin at 2.5 mg kg-1 body weight. In the first experiment, whole brains were collected 2, 6, 12, 24 and 48 h postdosing and analyzed for monoamines by high performance liquid chromatography with electro-chemical detection. T-2 toxin did not influence whole brain concentrations of monoamines in either species. In the second experiment, brains were collected 24 h postdosing, dissected into five brain regions, and analyzed for monoamines. T-2 toxin treatment resulted in increased serotonin and 5-hydroxy-3-indoleacetic acid in all brain regions of the rat. However, this was not seen in poultry where T-2 toxin treatment resulted in an increase in 5-hydroxy-3-indoleacetic acid, no alteration in serotonin concentration and a decrease in regional norepinephrine and dopamine concentrations. These results suggest that T-2 toxin influences brain biogenic amine metabolism and that there is an intraspecies difference in the central effects of this mycotoxin. | lld:pubmed |
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| pubmed-article:2453262 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2453262 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2453262 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2453262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2453262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2453262 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2453262 | pubmed:issn | 0830-9000 | lld:pubmed |
| pubmed-article:2453262 | pubmed:author | pubmed-author:WilsonJ RJR | lld:pubmed |
| pubmed-article:2453262 | pubmed:author | pubmed-author:WilsonL MLM | lld:pubmed |
| pubmed-article:2453262 | pubmed:author | pubmed-author:BoneD HDH | lld:pubmed |
| pubmed-article:2453262 | pubmed:author | pubmed-author:FitzpatrickD... | lld:pubmed |
| pubmed-article:2453262 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2453262 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:2453262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2453262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2453262 | pubmed:pagination | 181-5 | lld:pubmed |
| pubmed-article:2453262 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2453262 | pubmed:meshHeading | pubmed-meshheading:2453262-... | lld:pubmed |
| pubmed-article:2453262 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2453262 | pubmed:articleTitle | Effect of T-2 toxin on brain biogenic monoamines in rats and chickens. | lld:pubmed |
| pubmed-article:2453262 | pubmed:affiliation | Department of Foods and Nutritition, University of Manitoba, Winnipeg. | lld:pubmed |
| pubmed-article:2453262 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2453262 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
