| pubmed-article:2451346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C1623048 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C1446680 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0449943 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:2451346 | lifeskim:mentions | umls-concept:C0027971 | lld:lifeskim |
| pubmed-article:2451346 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2451346 | pubmed:dateCreated | 1988-5-2 | lld:pubmed |
| pubmed-article:2451346 | pubmed:abstractText | Antigenic variants of the New Jersey serotype of vesicular stomatitis virus (VSV-NJ) were isolated and cloned by selecting virus plaques resistant to neutralization by high-titered monoclonal antibodies (MAbs) directed to glycoprotein (G) epitopes V, VI, VII, or VIII. The G proteins of each neutralization-resistant virus variant also exhibited markedly reduced antigenic reactivity with each corresponding epitope-specific MAb as determined by enzyme-linked immuno-absorbent assay and by Western blot analysis. Loss of antigenic reactivity of certain mutant G proteins to a MAb other than the one used to select the mutant virus suggested close antigenic proximity, particularly for epitopes VI and VII. The virion RNAs coding for the entire G gene of the wild-type virus and 10 MAb-induced mutants were sequenced by primer DNA extension using the dideoxy method. Each mutant G gene exhibited only a single nucleotide change, leading in each case to a single amino acid substitution, as follows: Glu210----Lys for all three mutants selected by MAb14 (epitope VII); Pro268----Thr for one mutant selected by MAb12 (epitope VI); Ser277----Lys for all three mutants selected by MAb15 (epitope VIII); and Glu364----Lys for all three mutants selected by MAb11 (epitope V). These neutralizing MAb-selected mutations are clustered in the middle third of the 517-amino acid VSV-NJ G protein, presumably resulting in conformational changes that alter recognition of one or more antigenic determinants by a specific monoclonal antibody. | lld:pubmed |
| pubmed-article:2451346 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2451346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2451346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2451346 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2451346 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:2451346 | pubmed:author | pubmed-author:LUMM | lld:pubmed |
| pubmed-article:2451346 | pubmed:author | pubmed-author:WagnerR RRR | lld:pubmed |
| pubmed-article:2451346 | pubmed:author | pubmed-author:SnyderR MRM | lld:pubmed |
| pubmed-article:2451346 | pubmed:author | pubmed-author:WULL | lld:pubmed |
| pubmed-article:2451346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2451346 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:2451346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2451346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2451346 | pubmed:pagination | 341-8 | lld:pubmed |
| pubmed-article:2451346 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:meshHeading | pubmed-meshheading:2451346-... | lld:pubmed |
| pubmed-article:2451346 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2451346 | pubmed:articleTitle | Point mutations in glycoprotein gene of vesicular stomatitis virus (New Jersey serotype) selected by resistance to neutralization by epitope-specific monoclonal antibodies. | lld:pubmed |
| pubmed-article:2451346 | pubmed:affiliation | Department of Microbiology and Cancer Center, University of Virginia School of Medicine, Charlottesville 22908. | lld:pubmed |
| pubmed-article:2451346 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2451346 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2451346 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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