| pubmed-article:2451117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2451117 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:2451117 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:2451117 | lifeskim:mentions | umls-concept:C0085237 | lld:lifeskim |
| pubmed-article:2451117 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2451117 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2451117 | pubmed:dateCreated | 1988-4-28 | lld:pubmed |
| pubmed-article:2451117 | pubmed:abstractText | The antiarrhythmic action of type I antiarrhythmic drugs may be mediated via binding of the drugs to a receptor associated with the cardiac sodium channel. This suggested that the effects of type I drugs might be stereospecific. We measured the effect of the tocainide stereoisomers (which have stereospecific antiarrhythmic effects) on conduction time and on radioligand binding to the cardiac sodium channel. The concentration-dependent effects of the individual enantiomers of tocainide on interventricular conduction time measured during constant rate ventricular pacing at 350 msec were assessed in 47 isolated perfused rabbit heart preparations. Significant increases (p less than 0.05) in conduction time occurred for both R-(-)-tocainide (75 microM, 10 +/- 5 msec) and S-(+)-tocainide (150 microM, 4 +/- 1 msec). R-(-)-Tocainide was more potent than the S-(+)-tocainide in prolonging conduction time (p less than 0.05). This stereospecific prolongation of conduction time suggested a stereospecific interaction with the sodium channel. The affinities of the enantiomers for the channel were measured with a radioligand binding assay using [3H]batrachotoxinin benzoate and freshly isolated cardiac myocytes. Both enantiomers inhibited [3H]batrachotoxin benzoate binding, but the IC50 (+/- SD) values were different: R-(-)-tocainide 184 +/- 8 microM; S-(+)-tocainide, 546 +/- 37 microM (p less than 0.003). Tocainide isomers are stereospecific in terms of prolonging conduction time and in binding to the sodium channel. The stereospecific electrophysiologic effects of tocainide may result from binding to a receptor associated with the cardiac sodium channel. | lld:pubmed |
| pubmed-article:2451117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2451117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2451117 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2451117 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:2451117 | pubmed:author | pubmed-author:NiesA SAS | lld:pubmed |
| pubmed-article:2451117 | pubmed:author | pubmed-author:CannonN JNJ | lld:pubmed |
| pubmed-article:2451117 | pubmed:author | pubmed-author:SheldonR SRS | lld:pubmed |
| pubmed-article:2451117 | pubmed:author | pubmed-author:DuffH JHJ | lld:pubmed |
| pubmed-article:2451117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2451117 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:2451117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2451117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2451117 | pubmed:pagination | 327-31 | lld:pubmed |
| pubmed-article:2451117 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
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| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
| pubmed-article:2451117 | pubmed:meshHeading | pubmed-meshheading:2451117-... | lld:pubmed |
| pubmed-article:2451117 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2451117 | pubmed:articleTitle | Stereospecific interaction of tocainide with the cardiac sodium channel. | lld:pubmed |
| pubmed-article:2451117 | pubmed:affiliation | Department of Medicine, University of Calgary, Alberta, Canada. | lld:pubmed |
| pubmed-article:2451117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2451117 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2451117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2451117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2451117 | lld:pubmed |
