| pubmed-article:2450346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0003593 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0205666 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0242611 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:2450346 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:2450346 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2450346 | pubmed:dateCreated | 1988-4-19 | lld:pubmed |
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| pubmed-article:2450346 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2450346 | pubmed:abstractText | Human apolipoprotein B (apoB) is present in plasma as two separate isoproteins, designated apoB-100 (512 kDa) and apoB-48 (250 kDa). ApoB is encoded by a single gene on chromosome 2, and a single nuclear mRNA is edited and processed into two separate apoB mRNAs. A 14.1-kilobase apoB mRNA codes for apoB-100, and the second mRNA, which codes for apoB-48, contains a premature stop codon generated by a single base substitution of cytosine to uracil at nucleotide 6538, which converts the translated CAA codon coding for the amino acid glutamine at residue 2153 in apoB-100 to a premature in-frame stop codon (UAA). Two 30-base synthetic oligonucleotides (nucleotides 6523-6552 of apoB mRNA), designated apoB-Stop and apoB-Gln, were synthesized containing the complementary sequence to the stop codon (UAA) and glutamine codon (CAA), respectively. Analysis of intestinal apoB mRNA by hybridization with apoB-Stop and apoB-Gln probes and sequence analysis of apoB clones in two independent human small intestinal cDNA libraries established that intestinal apoB mRNA contained both the apoB mRNA that codes for apoB-100 and the apoB mRNA containing the premature in-frame stop codon, which codes for apoB-48. Investigation of hepatic apoB mRNA and two hepatic cDNA libraries by hybridization with the apoB-Stop and apoB-Gln synthetic probes as well as by cDNA sequencing revealed that liver apoB mRNA also contains both the apoB-100 mRNA and the apoB-48 mRNA containing the stop codon. The combined results from these studies establish that both human intestine and liver contain the two distinct apoB mRNAs, an mRNA that codes for apoB-100 and an apoB mRNA that contains the premature stop codon, which codes for apoB-48. The premature in-frame stop codon is not tissue specific and is present in both human liver and intestine. | lld:pubmed |
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| pubmed-article:2450346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2450346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2450346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2450346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2450346 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2450346 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:BrewerH BHBJr | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:LawS WSW | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:HospattankarA... | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:HiguchiKK | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:MeglinNN | lld:pubmed |
| pubmed-article:2450346 | pubmed:author | pubmed-author:CortrightJJ | lld:pubmed |
| pubmed-article:2450346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2450346 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2450346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2450346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2450346 | pubmed:pagination | 1772-6 | lld:pubmed |
| pubmed-article:2450346 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2450346 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2450346 | pubmed:articleTitle | Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine. | lld:pubmed |
| pubmed-article:2450346 | pubmed:affiliation | Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:2450346 | pubmed:publicationType | Journal Article | lld:pubmed |
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