| pubmed-article:2444593 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C0029463 | lld:lifeskim |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:2444593 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:2444593 | pubmed:issue | 31 | lld:pubmed |
| pubmed-article:2444593 | pubmed:dateCreated | 1987-12-10 | lld:pubmed |
| pubmed-article:2444593 | pubmed:abstractText | The effects of protein kinase C stimulation on free cytosolic Ca2+ [( Ca2+]i) were studied in Fura 2-loaded UMR-106 cells. Stimulation of the protein kinase C with the tumor-promoting phorbol esters 12-O-tetradecanoylphorbol 13-acetate (TPA) and phorbol 12,13-diacetate or 1-oleoyl-2-acetylglycerol was followed by an increase in [Ca2+]i. The protein kinase C-induced increase in [Ca2+]i has a lag period, the duration of which was dependent on the stimulant and medium Ca2+ concentrations. With 2 microM TPA, the rise in [Ca2+]i peaked within 1.5 min, after which [Ca2+]i returned partially toward base line. The increase in [Ca2+]i was absolutely dependent on the presence of medium Ca2+ and was inhibited by the Ca2+ channel blockers nicardipine and verapamil. Cell stimulation also results in Ca2+ release from intracellular pool(s) which appears to be mediated by a Ca2+-dependent Ca2+ release mechanism. The reduction in [Ca2+]i was due to channel inactivation. Pretreatment of the cells with 1 nM TPA, 2 units/ml parathyroid hormone (PTH), or 15 microM forskolin blocked the effect of 2 microM TPA on [Ca2+]i. TPA and PTH were more potent inhibitors than was forskolin. The properties of this channel are compared to the cAMP-independent PTH-stimulated Ca2+ channel present in these cells. | lld:pubmed |
| pubmed-article:2444593 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2444593 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2444593 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2444593 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2444593 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2444593 | pubmed:author | pubmed-author:KleemanC RCR | lld:pubmed |
| pubmed-article:2444593 | pubmed:author | pubmed-author:YamaguchiD... | lld:pubmed |
| pubmed-article:2444593 | pubmed:author | pubmed-author:MuallemSS | lld:pubmed |
| pubmed-article:2444593 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2444593 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2444593 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:2444593 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2444593 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2444593 | pubmed:pagination | 14967-73 | lld:pubmed |
| pubmed-article:2444593 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2444593 | pubmed:meshHeading | pubmed-meshheading:2444593-... | lld:pubmed |
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| pubmed-article:2444593 | pubmed:meshHeading | pubmed-meshheading:2444593-... | lld:pubmed |
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| pubmed-article:2444593 | pubmed:meshHeading | pubmed-meshheading:2444593-... | lld:pubmed |
| pubmed-article:2444593 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2444593 | pubmed:articleTitle | Protein kinase C-activated calcium channel in the osteoblast-like clonal osteosarcoma cell line UMR-106. | lld:pubmed |
| pubmed-article:2444593 | pubmed:affiliation | Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048. | lld:pubmed |
| pubmed-article:2444593 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2444593 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2444593 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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