| pubmed-article:2443641 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0004827 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C1325893 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:2443641 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2443641 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2443641 | pubmed:dateCreated | 1987-11-5 | lld:pubmed |
| pubmed-article:2443641 | pubmed:abstractText | Adenosine inhibits immunoglobulin E-dependent histamine release when preincubated with human basophil leukocytes before challenge. Two distinct mechanisms for this inhibition have been demonstrated. The first we suggest to be an A2-purinoceptor mediated mechanism. This effect, which is apparent with both 15- and 60-min preincubation periods, is mimicked by 5'-N-ethylcarboxamideadenosine, blocked by 8-phenyltheophylline but not dipyridamole and is associated with the ability of adenosine to elevate cyclic AMP. The second, which is mimicked by 3-deazaadenosine and is associated only with the longer 60-min preincubation period, is reversed by dipyridamole but not by 8-phenyltheophylline suggesting it to be an intracellular mechanism. Its enhancement by homocysteine thiolactone and reversal by exogenous S-adenosyl methionine suggests it to result from increasing intracellular S-adenosyl homocysteine levels. Our failure to detect increased 3H-methyl incorporation into chloroform-methanol extractable lipids after immunoglobulin E-dependent activation would indicate that inhibition of S-adenosyl methionine methylation reactions are an unlikely mechanism. As both prior stimulation of A2-purinoceptors and elevation of intracellular S-adenosyl homocysteine enhance and prolong the cyclic AMP response consequent upon immunoglobulin E-dependent activation, this represents a common mechanism by which histamine release may be suppressed. | lld:pubmed |
| pubmed-article:2443641 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2443641 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443641 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2443641 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2443641 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:2443641 | pubmed:author | pubmed-author:ChurchM KMK | lld:pubmed |
| pubmed-article:2443641 | pubmed:author | pubmed-author:HughesP JPJ | lld:pubmed |
| pubmed-article:2443641 | pubmed:author | pubmed-author:BenyonR CRC | lld:pubmed |
| pubmed-article:2443641 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2443641 | pubmed:volume | 242 | lld:pubmed |
| pubmed-article:2443641 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2443641 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2443641 | pubmed:pagination | 1064-70 | lld:pubmed |
| pubmed-article:2443641 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2443641 | pubmed:meshHeading | pubmed-meshheading:2443641-... | lld:pubmed |
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| pubmed-article:2443641 | pubmed:meshHeading | pubmed-meshheading:2443641-... | lld:pubmed |
| pubmed-article:2443641 | pubmed:meshHeading | pubmed-meshheading:2443641-... | lld:pubmed |
| pubmed-article:2443641 | pubmed:meshHeading | pubmed-meshheading:2443641-... | lld:pubmed |
| pubmed-article:2443641 | pubmed:meshHeading | pubmed-meshheading:2443641-... | lld:pubmed |
| pubmed-article:2443641 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2443641 | pubmed:articleTitle | Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms. | lld:pubmed |
| pubmed-article:2443641 | pubmed:affiliation | Clinical Pharmacology, Southampton General Hospital. | lld:pubmed |
| pubmed-article:2443641 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2443641 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2443641 | lld:pubmed |
