| pubmed-article:2441025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C1325529 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0003195 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0010284 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2441025 | lifeskim:mentions | umls-concept:C0049971 | lld:lifeskim |
| pubmed-article:2441025 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2441025 | pubmed:dateCreated | 1987-8-31 | lld:pubmed |
| pubmed-article:2441025 | pubmed:abstractText | The effects of 711389-S, a new antiarrhythmic drug, on the sodium channel of crayfish giant axon were studied using micro-electrode and sucrose-gap voltage-clamp techniques. When applied externally, 711389-S suppressed the action potential and the rate of rise without affecting the resting membrane potential. Voltage-clamp experiments revealed that 711389-S inhibits the sodium current more selectively than the potassium current and that the inhibition is more evident with internal rather than external application. The inhibitory effect of internally applied 711389-S on sodium current was enhanced at less negative holding potentials. 711389-S also shifted the steady-state inactivation curve in the direction of hyperpolarization. Use-dependent block became evident in the 711389-S-treated axons; this block resulted from an increase in the slow inactivating state during repetitive depolarization and from a slow recovery from the inactivated state during the pulse interval. 711389-S produced an additional inhibition when sodium channels were open at large depolarizations. This additional inhibition could be reversed by small depolarizations that opened the sodium channels. These observations suggest that 711389-S binds the resting, inactivated and open states of the sodium channel, resulting in a reduction of sodium channel availability. 711389-S also shifted the voltage dependence of peak sodium conductance toward a less negative potential. | lld:pubmed |
| pubmed-article:2441025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2441025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2441025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2441025 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2441025 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:2441025 | pubmed:author | pubmed-author:FujiwaraMM | lld:pubmed |
| pubmed-article:2441025 | pubmed:author | pubmed-author:MuramatsuII | lld:pubmed |
| pubmed-article:2441025 | pubmed:author | pubmed-author:NodaMM | lld:pubmed |
| pubmed-article:2441025 | pubmed:author | pubmed-author:NishioMM | lld:pubmed |
| pubmed-article:2441025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2441025 | pubmed:volume | 242 | lld:pubmed |
| pubmed-article:2441025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2441025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2441025 | pubmed:pagination | 269-76 | lld:pubmed |
| pubmed-article:2441025 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2441025 | pubmed:meshHeading | pubmed-meshheading:2441025-... | lld:pubmed |
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| pubmed-article:2441025 | pubmed:meshHeading | pubmed-meshheading:2441025-... | lld:pubmed |
| pubmed-article:2441025 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2441025 | pubmed:articleTitle | Mechanism of sodium channel block in crayfish giant axons by 711389-S, a new antiarrhythmic drug. | lld:pubmed |
| pubmed-article:2441025 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2441025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2441025 | lld:pubmed |
